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Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes

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The Serotonin Receptors

Part of the book series: The Receptors ((REC))

Abstract

The purpose of this review is to examine experimental information concerning the structure and function of the G protein-coupled serotonin receptors in the three-dimensional context provided by the structure of rhodopsin. A critical examination of the suitability of rhodopsin as a template for serotonin receptor modeling from the level of sequence alignment to interpretation of biochemical experiments of relevance to the issues of structure-function relationships is presented.

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Author information

Authors and Affiliations

  1. Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA

    Richard B. Westkaemper

  2. Department of Biochemistry,Neuroscience, and Psychiatry, School of Medicine,Case Western Reserve University, Cleveland, OH, USA

    Bryan L. Roth

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  1. Richard B. Westkaemper
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  2. Bryan L. Roth
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Editors and Affiliations

  1. Department of Biochemistry, Case Western Reserve University-School of Medicine, Cleveland, OH

    Bryan L. Roth MD, PhD

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© 2006 Humana Press Inc., Totowa, NJ

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Westkaemper, R.B., Roth, B.L. (2006). Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes. In: Roth, B.L. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-080-5_2

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  • DOI: https://doi.org/10.1007/978-1-59745-080-5_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-568-2

  • Online ISBN: 978-1-59745-080-5

  • eBook Packages: MedicineMedicine (R0)

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