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Electrophysiological Properties of Gαs-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7)

  • Chapter
The Serotonin Receptors

Part of the book series: The Receptors ((REC))

Abstract

Serotonin receptors of the 5-HT4 and 5-HT7 subtypes couple to heterotrimeric G proteins of the Gαs type and signal their electrophysiological effects by stimulating adenylate cyclase, increasing intracellular cAMP, and activating protein kinase A (PKA). These receptors, like many other receptors coupling to Gαs, modulate three classic currents in excitable tissues: the hyperpolarization-activated cation current I h , a calcium-activated potassium current generally known as I AHP , and the L-type calcium current. 5-HT4 and 5-HT7 receptors inhibit I SAHP and facilitate L-type calcium currents by increasing cAMP and activating PKA. However, these receptors facilitate I h by a direct effect of cAMP that is independent of PKA. Other currents might also contribute to the postsynaptic effects signaled by these receptors in specific neuronal cell types. Little is known at the present time regarding the electrophysiological responses signaled by the activation of 5-HT6 receptors. A key remaining question is how these receptors and currents are regulated by synaptically released serotonin in a physiological context.

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Author information

Authors and Affiliations

  1. Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA

    Rodrigo Andrade

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  1. Rodrigo Andrade
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Editors and Affiliations

  1. Department of Biochemistry, Case Western Reserve University-School of Medicine, Cleveland, OH

    Bryan L. Roth MD, PhD

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© 2006 Humana Press Inc., Totowa, NJ

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Andrade, R. (2006). Electrophysiological Properties of Gαs-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7). In: Roth, B.L. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-080-5_16

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  • DOI: https://doi.org/10.1007/978-1-59745-080-5_16

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-568-2

  • Online ISBN: 978-1-59745-080-5

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