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The Serotonin Receptors pp 365–401Cite as

Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors

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Part of the book series: The Receptors ((REC))

Abstract

The 5-HT1A and 5-HT1B/1D receptors are major determinants of the activity of serotonergic cells and of serotonin, 5-hydroxytrytamine (5-HT), release because of their role as somatodendritic and terminal autoreceptors, respectively. As such, their physiological role is to limit unwanted increases in serotonergic activity and 5-HT release and play an important role in the action of drugs used to treat psychiatric diseases, like anxiety or depression. Additionally, those receptors are located postsynaptically to serotonergic axons, in cortical, limbic, and hypothalamic areas (5-HT1A receptors), and in the basal ganglia (5-HT1B receptors). 5-HT, acting on those postsynaptic receptors, is involved in cognition, mood, impulse control, and motor functions by modulating the activity of different neuronal types and inhibiting the release of various neurotransmitters, such as glutamate, GABA, acetylcholine, and dopamine.

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  1. Department of Neurochemistry, Institut d’ Investigacions Biomèdiques de Barcelona (CSIC), IDIBAPS, 08036 Barcelona, Spain

    Pau Celada, Albert Adell & Francesc Artigas

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  1. Pau Celada
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  1. Department of Biochemistry, Case Western Reserve University-School of Medicine, Cleveland, OH

    Bryan L. Roth MD, PhD

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Celada, P., Adell, A., Artigas, F. (2006). Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors. In: Roth, B.L. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-080-5_11

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