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Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors

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The Serotonin Receptors

Part of the book series: The Receptors ((REC))

Abstract

Among animals with nervous systems, serotonin (5-hydroxytryptamine; 5-HT) is a ubiquitous neurotransmitter, and numerous classes and subclasses of G protein-coupled 5-HT receptors have evolved to transduce extracellular 5-HT signals to the intracellular milieu. In this chapter, we summarize naturally occurring variation in serotonin receptor sequences. These sequences vary by species and by class and subclass and are further modified from their canonical sequences by RNA editing, alternative splicing, and the existence of single-nucleotide polymorphisms. By the presence of 5-HT receptors in such relatively simple organisms as Caenorhabditis elegans, it can be inferred that serotonergic signaling as a means of intracellular communication arose fairly early in evolutionary history. The multiple subclasses of 5-HT receptors and the various means to further modify receptor sequences, such as splicing and editing, presumably point to a biological requirement for very delicate “fine-tuning” of serotonergic signaling. How this fine-tuning is accomplished is likely to occupy and intrigue biologists for many years.

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  1. Wesley K. Kroeze
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  1. Department of Biochemistry, Case Western Reserve University-School of Medicine, Cleveland, OH

    Bryan L. Roth MD, PhD

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Kroeze, W.K., Roth, B.L. (2006). Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors. In: Roth, B.L. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-080-5_1

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