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AMPA Receptors

  • Chapter
The Glutamate Receptors

Part of the book series: The Receptors ((REC))

Summary

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMP ARs) are glutamate-gated ion channels. They are the neurotransmitter receptors that mediate the great majority of fast excitatory synaptic transmission in the mammalian brain and are found throughout the animal kingdom in organisms as diverse as rodents, honeybees, nematode worms, and humans. They are absolutely critical for brain function; for example, infusion of a selective AMPAR antagonist into the rat hippocampus in vivo completely silences excitatory transmission in that region (1). AMPARs are also required for adaptive changes in the brain, mediating the expression of forms of long-term and short-term synaptic plasticity that are believed to underlie learning and memory, development, and certain neurologic diseases (2-5). Thus, AMPARs play a central role in brain function, and consequently there is great interest in the development of novel therapies directed at modulating AMPAR function for treatment of neurologic disorders, such as Alzheimer disease and stroke.

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Authors
  1. Michael C. Ashby
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  2. Michael I. Daw
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  3. John T.R. Isaac
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology and Biological Chemistry Department of Anatomy and Neurobiology, Washington University Pain Center Washington University School of Medicine, St. Louis, MO

    Robert W. Gereau PhD

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL

    Geoffrey T. Swanson PhD

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© 2008 Humana Press

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Ashby, M.C., Daw, M.I., Isaac, J.T. (2008). AMPA Receptors. In: Gereau, R.W., Swanson, G.T. (eds) The Glutamate Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-055-3_1

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