Skip to main content
SpringerLink
Log in
Book cover

Cardiovascular Biomarkers pp 139–159Cite as

Cardiac Troponin in Conditions Other Than Acute Coronary Syndromes

  • Chapter

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

This chapter reviews the evidence-based literature demonstrating increased cardiac troponins in patients presenting without ischemic heart disease. In several clinical settings, increased cardiac troponin is associated with both short- and long-term adverse outcomes. In addition, mechanisms responsible for analytical false-positive cardiac troponin results are addressed.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jaffe AS, Ravkilde J, Roberts R, et al. It’s time for a change to a troponin standard. Circulation 2000; 102:1216–1220.

    PubMed  CAS  Google Scholar 

  2. Joint European Society of Cardiology/American College of Cardiology Committee. Myocardial infarction defined-a consensus document of the joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000;36: 959–969.

    Article  Google Scholar 

  3. Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction. J Am Coll Cardiol 2000; 36:970–1062.

    Article  PubMed  CAS  Google Scholar 

  4. Apple FS, Wu AHB, Jaffe AS. European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials. Am Heart J 2002;144:981–986.

    Article  PubMed  Google Scholar 

  5. Apple FS. Tissue specificity of cardiac troponin I, cardiac troponin T, and creatine kinase MB. Clin Chim Acta 1999;284:151–159.

    Article  PubMed  CAS  Google Scholar 

  6. Apple FS, Wu AHB, Valdes R Jr. Serum cardiac troponin T concentrations in hospitalized patients without acute myocardial infarction. Scand J Clin Lab Invest 1996;56:63–68.

    Article  PubMed  CAS  Google Scholar 

  7. Herman Eugene, Ferrans VJ. The use of cardiac biomarkers for the detection of drug-induced myocardial damage. In: Wu AHB, ed. Markers in Cardiology. Humana, Totowa, NJ, 2001, pp. 211–234.

    Google Scholar 

  8. Setsuta K, Seino Y, Takahashi N, et al. Clinical significance of elevated levels of cardiac troponin T in patients with chronic heart failure. Am J Cardiol 1999;84:608–611.

    Article  PubMed  CAS  Google Scholar 

  9. Horwich T, Patel J, MacLellan R, Fonarow G. Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation 2003;108:833–838.

    Article  PubMed  CAS  Google Scholar 

  10. Del Carlo C, O’Connor C. Cardiac troponins in congestive heart failure. Am Heart J 1999;138:646–653.

    Article  PubMed  CAS  Google Scholar 

  11. Vecchia L, Mezzena G, Ometto R, et al. Detectable serum troponin I in patients with heart failure of non-myocardial ischemic origin. Brief Reports 1997:88–90.

    Google Scholar 

  12. Missov E, Mair J. A novel biochemical approach to congestive heart failure: cardiac troponin T. Am Heart J 1999;138:95–99.

    Article  PubMed  CAS  Google Scholar 

  13. Mair P, Mair J, Koller J, et al. Cardiac troponin T release in multiply injured patients. Injury 1995;26: 439–443.

    Article  PubMed  CAS  Google Scholar 

  14. Bertinchant J, Polge A, Mohty D, et al. Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with suspected myocardial contusion after blunt chest trauma. J Trauma Inj Crit Care 2000;48:824–831.

    Google Scholar 

  15. Adams J, Davila-Roman V, Bessey P, et al. Improved detection of cardiac contusion with cardiac troponin I. Am Heart J 1996;131:308–312.

    Article  PubMed  Google Scholar 

  16. Mair P, Mair J, Koller J, et al. Cardiac troponin T in the diagnosis of heart contusion. Lancet 1991; 338:693.

    Article  PubMed  CAS  Google Scholar 

  17. Salim A, Velmahos GC, Jindal A, et al. Clinically significant blunt cardiac trauma: role of serum troponin levels combined with electrocardiographic findings. J Trauma 2001;50:237–243.

    Article  PubMed  CAS  Google Scholar 

  18. Fulda GJ, Giberson F, Hailstone D, Law A, Stillabower M. An evaluation of serum troponin T and signal-averaged electrocardiography in predicting electrocardiographic abnormalities after blunt chest trauma. J Trauma 1997;43:304–310.

    Article  PubMed  CAS  Google Scholar 

  19. Georges J, Spentchian M, Caubel C, et al. Time course of troponin I, myoglobin, and cardiac enzyme release after electrical cardioversion. Am J Cardiol 1996;78:825–827.

    Article  PubMed  CAS  Google Scholar 

  20. Runsio M, Kallner A, Kallner G, Rosenqvist M, Bergfeldt L. Myocardial injury after electrical therapy for cardiac arrhythmias assessed by troponin-T release. Am J Cardiol 1997;79:1241–1245.

    Article  PubMed  CAS  Google Scholar 

  21. Bonnefoy E, Chevalier P, Kirkorian G, et al. Cardiac troponin I does not increase after cardioversion. Clin Invest Crit Care 1997;111:15–18.

    CAS  Google Scholar 

  22. Joglar J, Kessler D, Welch P, et al. Effects of repeated electrical defibrillations on cardiac troponin I levels. Brief Rep 1999:270–272.

    Google Scholar 

  23. Boriani G, Biffi M, Cervi V, et al. Evaluation of myocardial injury following repeated internal atrial shocks by monitoring serum cardiac troponin I levels. Clin Invest Crit Care 2000;118:342–347.

    CAS  Google Scholar 

  24. Meyer T, Binder L, Hruska N, Luthe H, Buchwald A. Cardiac troponin I elevation in acute pulmonary embolism is associated with right ventricular dysfunction. J Am Coll Cardiol 2000;36:1632–1636.

    Article  PubMed  CAS  Google Scholar 

  25. Giannitsis E, Muller-Bardorff M, Kurowski V, et al. Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism. Circulation 2000;102:211–217.

    PubMed  CAS  Google Scholar 

  26. Konstantinides S, Geibel A, Olschewski M, et al. Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism. Circulation 2002;106:1263–1268.

    Article  PubMed  CAS  Google Scholar 

  27. Fernandes CJ, Akamine N, Knobel E. Cardiac troponin: a new serum marker of myocardial injury in sepsis. Intensive Care Med 1999;25:1165–1168.

    Article  PubMed  Google Scholar 

  28. Ammann P, Fehr T, Minder EI, Gunter C, Bertel O. Elevation of troponin I in sepsis and septic shock. Intensive Care Med 2001;27:965–969.

    Article  PubMed  CAS  Google Scholar 

  29. Giroir BP, Stromberg D. Myocardial depression versus myocardial destruction: integrating the multiple mechanisms of myocardial dysfunction during sepsis. Crit Care Med 2000;28:3111–3112.

    Article  PubMed  CAS  Google Scholar 

  30. Spies C, Haude V, Fitzner R, et al. Serum cardiac troponin T as a prognostic marker in early sepsis. Chest 1998;113:1055–1063.

    Article  PubMed  CAS  Google Scholar 

  31. ver Elst K, Spapen H, Nguyen D, et al. Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clin Chem 2000;46:650–657.

    Google Scholar 

  32. Ammann P, Fehr T, Minder EI, Gunter C, Bertel O. Elevation of troponin I in sepsis and septic shock. Intensive Care Med 2001;27:965–969.

    Article  PubMed  CAS  Google Scholar 

  33. Wu A. Increased troponin in patients with sepsis and septic shock: myocardial necrosis or reversible myocardial depression? Intensive Care Med 2001;27:959–961.

    Article  PubMed  CAS  Google Scholar 

  34. Guest T, Ramanathan A, Tuteur P, et al. Myocardial injury in critically ill patients: a frequently unrecognized complication. JAMA 1995;273:1945–1949.

    Article  PubMed  CAS  Google Scholar 

  35. Kollef M, Ladenson J, Eisenberg P. Clinically recognized cardiac dysfunction: an independent determinant of mortality among critically ill patients: is there a role for serial measurement of cardiac troponin I? Clin Invest Crit Care 1997;111:1340–1347.

    CAS  Google Scholar 

  36. Ammann P, Maggiorini M, Bertel O, et al. Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes. J Am Coll Cardiol 2003;41:2004–2009.

    Article  PubMed  CAS  Google Scholar 

  37. Wright R, Williams B, Cramner H, et al. Elevations of cardiac troponin I are associated with increased short-term mortality in non-cardiac critically ill emergency department patients. Am J Cardiol 2002; 90:634–636.

    Article  PubMed  CAS  Google Scholar 

  38. Bachmaier K, Mair J, Offner F, Pummerer C, Neu N. Serum cardiac troponin T and creatine kinase-MB elevations in murine autoimmune myocarditis. Circulation 1995;92:1927–1932.

    PubMed  CAS  Google Scholar 

  39. Smith S, Ladenson J, Mason J, Jaffe A. Elevations of cardiac troponin I associated with myocarditis. Circulation 1997;95:163–168.

    PubMed  CAS  Google Scholar 

  40. Lauer B, Niederau C, Kuhl U, et al. Cardiac troponin T in patients with clinically suspected myocarditis. J Am Coll Cardiol 1997;30:1354–1359.

    Article  PubMed  CAS  Google Scholar 

  41. Franz W, Remppis A, Kandolf R, Kubler W, Katus H. Serum troponin T: diagnostic marker for acute myocarditis. Clin Chem 1996;42:340–341.

    PubMed  CAS  Google Scholar 

  42. Feldman AM, McNamara D. Myocarditis. N Engl J Med 2000;343:1388–1398.

    Article  PubMed  CAS  Google Scholar 

  43. James P, Ellis C, Whitlock R, et al. Relation between troponin T concentration and mortality in patients presenting with an acute stroke: observational study. Br Med J 2000;320:1502–1504.

    Article  CAS  Google Scholar 

  44. Ay H, Arsava E, Saribas O. Creatine kinase-MB elevation after stroke is not cardiac in origin: comparison with troponin T levels. Stroke 2002;33:286–289.

    Article  PubMed  CAS  Google Scholar 

  45. Etgen T, Baum H, Sander K, Sander D. Cardiac troponins and N-terminal pro-brain natriuretic peptide in acute ischemic stroke do not relate to clinical prognosis. Stroke 2005;36:270–275.

    Article  PubMed  CAS  Google Scholar 

  46. Adams J, Sicard GR, Allen B, et al. Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I. N Engl J Med 1994;330:670–674.

    Article  PubMed  Google Scholar 

  47. Goldman, L. Assessment of peri-operative cardiac risk. N Engl J Med 1994;330:707–709.

    Article  PubMed  CAS  Google Scholar 

  48. Kim L, Martinez E, Faraday N, et al. Cardiac troponin I predicts short-term mortality in vascular surgery patients. Am Heart J 2002;106:2366–2371.

    CAS  Google Scholar 

  49. Efthimiadis A, Cheiridou M, Lefkos N, et al. The predictive value of troponin T in patients who underwent an extracardiac surgery operation. Acta Cardiol 1995;L:309–313.

    Google Scholar 

  50. Metzler H, Gries M, Rehak P, et al. Perioperative myocardial cell injury: the role of troponins. Br J Anaesth 1997;78:386–390.

    PubMed  CAS  Google Scholar 

  51. Rifai N, Douglas PS, O’Toole M, Rimm E, Ginsburg G. Cardiac troponin T and I electrocardiographic wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. Am J Cardiol 1999;83:1085–1089.

    Article  PubMed  CAS  Google Scholar 

  52. Shave R, Dawson E, Whyte G, George K, Gaze D, Collinson P. Altered cardiac function and minimal cardiac damage during prolonged exercise. Med Sci Sports Exerc 2004;36:1098–1103.

    Article  PubMed  CAS  Google Scholar 

  53. Apple FS, Rhodes MD. Enzymatic estimation of skeletal muscle damage by analysis of changes in serum creatine kinase. J Appl Physiol 1988;65:2598–2600.

    PubMed  CAS  Google Scholar 

  54. Siegel AJ, Stec JJ, Lipinska I, et al. Effect of marathon running on inflammatory and hemostatic markers. Am J Cardiol 2001;88:918–920.

    Article  PubMed  CAS  Google Scholar 

  55. Chen Y, Serfass RC, Mackey-Bojack S, Kelly KL, Titus JL, Apple FS. Cardiac troponin T alterations in myocardium and serum of rats following stressful, prolonged intense exercise J Appl Physiol 2000; 88:1749–1755.

    PubMed  CAS  Google Scholar 

  56. Siegel AJ, Kewandroski KB, Strauss W, Fischman AJ, Yasuda T. Normal post-race antimyosin myocardial scintigraphy in asymptomatic marathon runners with elevated serum creatine kinase MB isoenzyme and troponin T levels. Cardiology 1995;86:451–456.

    Article  PubMed  CAS  Google Scholar 

  57. Cummins P, Young A, Auckland ML, Michie CA, Stone PCW, Shepstone BJ. Comparison of serum cardiac specific troponin-I with creatine kinase, creatine kinase-MB isoenzyme, tropomyosin, myoglobin and C-reactive protein release in marathon runners: cardiac or skeletal muscle trauma? Eur J Clin Invest 1987;17:317–324.

    Article  PubMed  CAS  Google Scholar 

  58. Laslett L, Eisenbud E. Lack of detection of myocardial injury during competitive races of 100 miles lasting 18 to 30 hours. Am J Cardiol 1997;80:379–380.

    Article  PubMed  CAS  Google Scholar 

  59. Adams JE, Bodor GS, Davila-Roman VG, et al. Cardiac troponin I: a high marker with high specificity for cardiac injury. Circulation 1993;88:101–106.

    PubMed  Google Scholar 

  60. Sorichter S, Mair J, Koller A, et al. Skeletal muscle troponin I release and magnetic resonance imaging signal intensity changes after eccentric exercise-induced skeletal muscle injury. Clin Chim Acta 1997; 262:139–146.

    Article  PubMed  CAS  Google Scholar 

  61. Collinson PO, Chandler HA, Stubbs PJ, Moseley DS, Lewis D, Simmons MD. Measurement of serum troponin T, creatine kinase MB isoenzyme, and total creatine kinase following arduous physical training. Ann Clin Biochem 1995;32:1–4.

    Google Scholar 

  62. Apple FS, Rogers MA, Sherman WM, Casal DC, Ivy JL. Creatine kinase MB isoenzyme adaptations in stressed human skeletal muscle. J Appl Physiol 1985;59:149–153.

    PubMed  CAS  Google Scholar 

  63. Apple FS, Rogers MA, Casal DC, Lewis L, Ivy JL, Lampe JW. Skeletal muscle creatine kinase MB alterations in women marathon runners. Eur J Appl Physiol 1987;56:49–52.

    Article  CAS  Google Scholar 

  64. Quivers E, Murthy J, Soldin S. The effect of gestational age, birth weight and disease on troponin I and creatine kinase MB in the first year of life. Clin Biochem 1999;32:419–421.

    Article  PubMed  CAS  Google Scholar 

  65. Shelton S, Fouse B, Holleman V, Sedor F, Herbert W. Cardiac troponin T levels in umbilical cord blood. Am J Obstet Gynecol 1999;181:1259–1262.

    Article  PubMed  CAS  Google Scholar 

  66. Hirsch R, Landt Y, Porter S, et al. Cardiac troponin I in pediatrics: normal values and potential use in the assessment of cardiac injury. J Pediatr 1997;130:872–877.

    Article  PubMed  CAS  Google Scholar 

  67. Adamcova M, Kokstein Z, Palicka V, Podholova M, Kostal M. Troponin T levels in the cord blood of healthy term neonates. Physiology 1995;44:99–104.

    CAS  Google Scholar 

  68. Shivvers S, Wians F Jr, Keffer J, Ramin S. Maternal cardiac troponin levels during normal labor and delivery. Am J Obstet Gynecol 1999;180:122.

    Article  PubMed  CAS  Google Scholar 

  69. Clark SJ, Newland P, Yoxall CW, Subhedar NV. Cardiac troponin T in cord blood. Arch Dis Child Fetal Neonatal Ed 2001;84:F34–F37.

    Article  PubMed  CAS  Google Scholar 

  70. Immer F, Stocker F, Seiler A, et al. Troponin-I for prediction of early post-operative course after pediatric cardiac surgery. J Am Coll Cardiol 1999;33:1719–1723.

    Article  PubMed  CAS  Google Scholar 

  71. Ganz W, Sridhar K, Ganz D, et al. Review of tests for monitoring doxorubicin-induced cardiomyopathy. Oncology 1996;53:461–470.

    Article  PubMed  CAS  Google Scholar 

  72. Herman E, Lipshultz S, Rifai N, et al. Use of cardiac troponin T levels as an indicator of doxorubicininduced cardiotoxicity. Cancer Res 1998;58:195–197.

    PubMed  CAS  Google Scholar 

  73. Cardinale D, Sandri M, Martinoni A, et al. Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy. J Am Coll Cardiol 2000;36:517–522.

    Article  PubMed  CAS  Google Scholar 

  74. Sandri MT, Cardianle D, Zorzino L, et al. Minor increases in plasma troponin I predict decreased left ventricular ejection fraction after high-dose chemotherapy. Clin Chem 2003;49:248–252.

    Article  PubMed  CAS  Google Scholar 

  75. Patel V, Ajmal R, Sherwood R, et al. Cardioprotective effect of propranolol from alcohol-induced heart muscle damage as assessed by plasma cardiac troponin-T. Alcohol Clin Exp Res 2001;25:882–889.

    Article  PubMed  CAS  Google Scholar 

  76. McLaurin M, Apple FS, Henry TD, Sharkey SW. Cardiac troponin I and T levels in patients with cocaine associated chest pain. Ann Clin Biochem 1996;33:183–186.

    PubMed  Google Scholar 

  77. Kushman S, Storrow A, Liu T, Gibler B. Cocaine-associated chest pain in a chest pain center. Am J Cardiol 2000;85:394–396.

    Article  PubMed  CAS  Google Scholar 

  78. Benghozi R, Bortolini M, Jia Y, et al. Frequency of creatine kinase elevation during treatment with fluvastatin. Am J Cardiol 2002;89:231–233.

    Article  PubMed  CAS  Google Scholar 

  79. Stelow R, Johari V, Smith S, Crosson J, Apple FS. Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings. Clin Chem 2000;46:577–581.

    PubMed  CAS  Google Scholar 

  80. Herzog CA, Ma JZ, Collings AJ. Poor long-term survival after acute myocardial infarction among patients on long-term dialysis. N Engl J Med 1998;339:779–805.

    Article  Google Scholar 

  81. Bleyer AJ, Russell GB, Satko SG. Sudden and cardiac death rates in hemodialysis patients. Kidney International 1999;55:1553–1559.

    Article  PubMed  CAS  Google Scholar 

  82. Lente F, McErlean E, DeLuca S, et al. Ability of troponins to predict adverse outcomes in patients with renal insufficiency and suspected acute coronary syndromes: a case-matched study. J Am Coll Cardiol 1999;33:471–478.

    Article  PubMed  Google Scholar 

  83. Ooi D, Zimmerman D, Graham J, Wells G. Cardiac troponin T predicts long-term outcomes in hemodialysis patients. Clin Chem 2001;47:412–417.

    PubMed  CAS  Google Scholar 

  84. McCullough P, Nowak R, Foreback C, et al. Performance of multiple cardiac biomarkers measured in the emergency department in patients with chronic kidney disease and chest pain. Acad Emerg Med 2002;9:1389–1396.

    Article  PubMed  Google Scholar 

  85. Iliou M, Fumeron C, Benoit M, et al. Factors associated with increased serum levels of cardiac troponins T and I in chronic haemodialysis patients: chronic haemodialysis and new cardiac markers evaluation (CHANCE) study. Nephrol Dial Transplant 2001;16:1452–1458.

    Article  PubMed  CAS  Google Scholar 

  86. Porter GA, Norton T, Bennett WM. Long-term follow-up of the utility of troponin T to assess cardiac risk in stable chronic hemodialysis patients. Clin Lab 2000;46:469–476.

    PubMed  CAS  Google Scholar 

  87. Dierkes J, Domrose U, Westphal D, et al. Cardiac troponin T predicts mortality in patients with endstage renal disease. J Am Coll Cardiol 2000;102:1964–1969.

    CAS  Google Scholar 

  88. Aviles R, Askari A, Lindahl B, et al. Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. N Engl J Med 2002;346:2047–2052, 2079–2082.

    Article  PubMed  CAS  Google Scholar 

  89. Lowbeer C, Ottosson-Seeberger A, Gustafsson S, et al. Increased cardiac troponin T and endothelin-1 concentrations in dialysis patients may indicate heart disease. Nephrol Dial Transplant 1999;14: 1948–1955.

    Article  PubMed  CAS  Google Scholar 

  90. Roppolo L, Fitzgerald R, Dillow J, et al. A comparison of troponin T and troponin I as predictors of cardiac events in patients undergoing chronic dialysis at a veteran’s hospital: a pilot study. J Am Coll Cardiol 1999;34:448–454.

    Article  PubMed  CAS  Google Scholar 

  91. Khan I, Wattanasuwan N, Mehta N, et al. Prognostic value of serum cardiac troponin I in ambulatory patients with chronic renal failure undergoing long-term hemodialysis. J Am Coll Cardiol 2001;38: 991–998.

    Article  PubMed  CAS  Google Scholar 

  92. Jaffe S. Editorial comment: testing the wrong hypothesis: the failure to recognize the limitations of troponin assays. J Am Coll Cardiol 2001;38:999–1001.

    Article  PubMed  CAS  Google Scholar 

  93. McLaurin M, Apple FS, Falahati A, et al. Cardiac troponin I and creatine kinase-MB mass to rule out myocardial injury in hospitalized patients with renal insufficiency. Am J Cardiol 1998;82:973–975.

    Article  PubMed  CAS  Google Scholar 

  94. Mockel M, Schindler R, Knorr L, et al. Prognostic value of cardiac troponin T and I elevations in renal disease patients without acute coronary syndromes: a 9-month outcome analysis. Nephrol Dial Transplant 1999;14:1489–1495.

    Article  PubMed  CAS  Google Scholar 

  95. Haller C, Zehelein J, Remppis S, Muller-Bardorff M, Katus H. Cardiac troponin T in patients with endstage renal disease: absence of expression in truncal skeletal muscle. Clin Chem 1998;44:930–938.

    PubMed  CAS  Google Scholar 

  96. Apple FS, Sharkey S, Hoeft P, et al. Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: a 1-year outcomes analysis. Am J Kidney Dis 1997;29:399–403.

    Article  PubMed  CAS  Google Scholar 

  97. McLaurin M, Apple FS, Voss E, Herzog C, Sharkey S. Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. Clin Chem 1997;43:976–982.

    PubMed  CAS  Google Scholar 

  98. Ishii J, Ishikawa T, Yukitake J, et al. Clinical specificity of a second-generation cardiac troponin T assay in patients with chronic renal failure. Clin Chim Acta 1998;270:183–188.

    Article  PubMed  CAS  Google Scholar 

  99. Frankel W, Herold D, Ziegler T, Fitzgerald R. Cardiac troponin T is elevated in asymptomatic patients with chronic renal failure. Clin Chem 1995;106:118–123.

    Google Scholar 

  100. Ellis K, Dreisbach A, Lertora J. Plasma elimination of cardiac troponin I in end-stage renal disease. South Med J 2001;94:993–996.

    PubMed  CAS  Google Scholar 

  101. Apple FS, Murakami MA, Pearce L, Herzog C. Predictive value of cardiac troponin I and T for subsequent death in end-stage renal disease. Circulation 2002:2941–2945.

    Google Scholar 

  102. Hamm C, Giannitsis E, Katus H. Cardiac troponin elevations in patients without acute coronary syndrome. Circulation 2002:2871,2872.

    Google Scholar 

  103. Roberts MA, Fernando D, Macmillan N, et al. Single and serial measurements of cardiac troponin I in asymptomatic patients of chronic hemodialysis. Clin Nephrol 2004;61:40–46.

    PubMed  CAS  Google Scholar 

  104. Diris J, Hackeng C, Kooman J, et al. Impaired renal clearance explains elevated troponin T fragments in hemodialysis patients. Circulation 2004:23–25.

    Google Scholar 

  105. Donnino M, Karriem-Norwood V, Rivers E, et al. Prevalence of elevated troponin I in end-stage renal disease patients receiving hemodialysis. Acad Emerg Med 2004;11:979–981.

    Article  PubMed  Google Scholar 

  106. Apple FS, Murakami MA, Pearce L, Herzog C. Multi-biomarker risk stratification on N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death. Clin Chem 2004;50:1–7.

    Article  CAS  Google Scholar 

  107. deFilippi C, Wasserman S, Rosanio S, et al. Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis. JAMA 2003;290:353–359.

    Article  PubMed  CAS  Google Scholar 

  108. Parekh N, Venkatesh B, Cross D, et al. Cardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage. J Am Coll Cardiol 2000;36:1328–1335.

    Article  PubMed  CAS  Google Scholar 

  109. Horowitz MB, Willet D, Keffer J. The use of cardiac troponin-I (cTnI) to determine the incidence of myocardial ischemia and injury in patients with aneurysmal and presumed aneurysmal subarachnoid hemorrhage. Acta Neurochir (Wien) 1998;140:87–93.

    Article  CAS  Google Scholar 

  110. Deibert E, Aiyagari V, Diringer MN. Reversible left ventricular dysfunction associated with raised troponin I after subarachnoid hemorrhage does not preclude successful heart transplantation. Heart 2000; 84:205–207.

    Article  PubMed  CAS  Google Scholar 

  111. Kobayashi S, Tanaka M, Tamura N, Hashimoto H, Hirose S. Serum cardiac troponin T in polymyositis/ dermatomyositis. Lancet 1992;340:726.

    Article  PubMed  CAS  Google Scholar 

  112. Lavoinne A, Hue G. Serum cardiac troponins I and T in early post-traumatic rhabdomyolysis. Clin Chem 1998;44:667–681.

    PubMed  CAS  Google Scholar 

  113. Lofberg M, Tahtela R, Harkonen M, Somer H. Cardiac troponins in severe rhabdomyolysis. Clin Chem 1996;42:1120,1121.

    PubMed  CAS  Google Scholar 

  114. Benoist J, Cosson C, Mimoz O, Edouard A. Serum cardiac troponin I, creatine kinase (CK), and CKMB in early post-traumatic rhabdomyolysis. Clin Chem 1997;43:416,417.

    PubMed  CAS  Google Scholar 

  115. Missov E, Calzolari C, Davy J, et al. Cardiac troponin I in patients with hematologic malignancies. Coron Artery Dis 1997;8:537–541.

    PubMed  CAS  Google Scholar 

  116. Bonnefoy E, Godon P, Kirkorian G, et al. Serum cardiac troponin I and ST-segment elevation in patients with acute pericarditis. Eur Heart J 2000;21:832–836.

    Article  PubMed  CAS  Google Scholar 

  117. Brandt R, Filzmaier K, Hanrath P. Circulating cardiac troponin I in acute pericarditis. Am J Cardiol 2001; 87:1326–1328.

    Article  PubMed  CAS  Google Scholar 

  118. Cina S, Thompson W, Fischer J, et al. A study of various morphologic variables and troponin I in pericardial fluid as possible discriminators of sudden cardiac death. Am J Forensic Med Pathol 1999;20: 333–337.

    Article  PubMed  CAS  Google Scholar 

  119. Weinberg I, Cukierman T, Chajek-Shaul T. Troponin T elevation in lobar lung disease. Postgrad Med J 2002;78:244,245.

    Article  PubMed  CAS  Google Scholar 

  120. Miller R, Callas DD, Kahn SE, Ricchiuti V, Apple FS. Evidence of myocardial damage in mummified human tissue. JAMA 2000;284:831,832.

    Article  PubMed  CAS  Google Scholar 

  121. Sharkey SW, Lesser JR, Zenovich AG, et al. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation 2005;111:472–479.

    Article  PubMed  Google Scholar 

  122. Wittstein IS, Thieman DR, Lima JAC, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005;352:539–548.

    Article  PubMed  CAS  Google Scholar 

  123. Katrukha A, Bereznikova A, Filatov V, Esakova T. Biochemical factors influencing measurement of cardiac troponin I in serum. Clin Chem Lab Med 1999;37:1091–1095.

    Article  PubMed  CAS  Google Scholar 

  124. Parry D, Krahn J, Leroux M, Dalton J. False-positive analytical interference of cardiac troponin I assays: an important consideration for method selection. Clin Biochem 1999;32:667–669.

    Article  PubMed  CAS  Google Scholar 

  125. Dasgupta A, Banerjee S, Datta P. False-positive troponin I in the MEIA due to the presence of rheumatoid factors in serum-elimination of this interference by using a polyclonal antisera against rheumatoid factors. Am J Clin Pathol 1999;112:753–756.

    PubMed  CAS  Google Scholar 

  126. McClennen S, Halamka J, Horowitz G, Kannam J, Ho K. Clinical prevalence and ramifications of false-positive cardiac troponin I elevations from the Abbott AxSYM analyser. Am J Cardiol 2003;91: 1125–1127.

    Article  PubMed  CAS  Google Scholar 

  127. Yeo K, Storm C, Li Y, et al. Performance of the enhanced Abbott AxSYM cardiac troponin I reagent in patients with heterophilic antibodies. Clin Chim Acta 2000;292:13–23.

    Article  PubMed  CAS  Google Scholar 

  128. Bohner J, Pape K, Hannes W, Stegmann T. False-negative immunoassay results for cardiac troponin I probably due to circulating troponin I autoantibodies. Clin Chem 1996;42:2046.

    PubMed  CAS  Google Scholar 

  129. Krahn J, Parry D, Leroux M, Dalton J. High percentage of false-positive cardiac troponin I results in patients with rheumatoid factor. Clin Biochem 1999;32:477–480.

    Article  PubMed  CAS  Google Scholar 

  130. Fitzmaurice T, Brown C, Rifai N, Wu A, Yeo K. False increase of cardiac troponin I with heterophilic antibodies. Clin Chem 1998;44:2212–2214.

    PubMed  CAS  Google Scholar 

  131. Nosanchuk J. False increases of troponin I attributable to incomplete separation of serum. Clin Chem 1999;45:714.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Laboratories, Hennepin County Medical Center, Minneapolis, MN

    Fred S. Apple PhD (Medical Director, Professor of Laboratory Medicine and Pathology)

  2. University of Minnesota School of Medicine, Minneapolis, MN

    Fred S. Apple PhD (Medical Director, Professor of Laboratory Medicine and Pathology)

  3. Cardiovascular Division, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA

    David A. Morrow MD, MPH (Assistant Professor of Medicine)

Authors
  1. Fred S. Apple PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Morrow MD, MPH
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    David A. Morrow MD, MPH

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Apple, F.S., Morrow, D.A. (2006). Cardiac Troponin in Conditions Other Than Acute Coronary Syndromes. In: Morrow, D.A. (eds) Cardiovascular Biomarkers. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-051-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-051-5_10

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-526-2

  • Online ISBN: 978-1-59745-051-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation