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Chemokine Receptors and Neutrophil Trafficking

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The Chemokine Receptors

Part of the book series: The Receptors ((REC))

Abstract

Neutrophils are the most abundant leukocytes in circulation. They rapidly infiltrate sites of tissue injury and play a critical role in innate immune responses. In addition, they also contribute to the development of adaptive immune responses. Isolation of the human chemokine IL-8 and the cloning of its receptors CXCR1 and CXCR2, followed by the cloning of their orthologues or homologues in animals, have enabled researchers to elucidate the mechanisms of neutrophil trafficking during immune responses at a molecular level. Since then, there has been tremendous progress in understanding how the trafficking of neutrophils is regulated by the chemokine/chemokine receptor system under not only pathologic but also physiologic conditions. In this chapter, the roles of the chemokine receptors in regulating the trafficking of neutrophils are described.

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Authors and Affiliations

  1. Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Frederick, MD, USA

    Teizo Yoshimura

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  1. Teizo Yoshimura
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Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL

    Jeffrey K. Harrison PhD

  2. Department of Pathology and Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI

    Nicholas W. Lukacs PhD

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© 2007 Humana Press Inc., Totowa, NJ

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Yoshimura, T. (2007). Chemokine Receptors and Neutrophil Trafficking. In: Harrison, J.K., Lukacs, N.W. (eds) The Chemokine Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-020-1_5

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