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Brachytherapy

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Essentials of Restenosis

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Postangioplasty restenosis has been the major limitation confronting interventional cardiology. The three major components of restenosis following balloon angioplasty are identified as an exuberant cellular proliferation and matrix synthesis (intimal hyperplasia) triggered by injury to the vessel wall (1–4), acute elastic recoil immediately following balloon deflation, and late vascular contraction (remodeling) resulting in a decrease in total vessel diameter (5–8). Coronary stenting eliminates elastic recoil and vessel contraction by acting as a mechanical scaffold within the vessel, thus reducing the restenosis rate (9,10). Stents, however, are associated with a higher degree of proliferative response and increase in lumen late loss (11).

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Authors and Affiliations

  1. Division of Cardiology, Washington Hospital Center, Washington, DC

    Ron Waksman MD

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  1. Ron Waksman MD
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Editors and Affiliations

  1. Thoraxcenter, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands

    Henricus J. Duckers MD, PhD  & Patrick W. Serruys MD, PhD  & 

  2. The Nabel Lab, Genome Technology Branch, NHGRI Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

    Elizabeth G. Nabel MD

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Waksman, R. (2007). Brachytherapy. In: Duckers, H.J., Nabel, E.G., Serruys, P.W. (eds) Essentials of Restenosis. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-001-0_20

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  • DOI: https://doi.org/10.1007/978-1-59745-001-0_20

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-491-3

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