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New Methods to Access Microbial Diversity for Small Molecule Discovery

  • Chapter
Natural Products

Abstract

Natural-product-derived drugs are a major portion of the total number of approved drugs in the antibacterial area. The majority of bacteria and fungi in the environment is only known by molecular fingerprints and has resisted cultivation. Therefore, new methods have been developed to access this tremendous microbial diversity for the discovery of novel small molecules. These culture-dependent and -independent methods include a novel high-throughput cultivation technology as well as a recombinant approach to discover and express novel natural products.

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Authors and Affiliations

  1. Diversa Corporation, San Diego, CA

    Karsten Zengler PhD, Ashish Paradkar PhD & Martin Keller PhD

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  1. Karsten Zengler PhD
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  2. Ashish Paradkar PhD
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  3. Martin Keller PhD
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Editors and Affiliations

  1. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

    Lixin Zhang PhD

  2. SynerZ Pharmaceuticals Inc., Lexington, MA

    Lixin Zhang PhD

  3. Charles A. Dana Research Institute (R.I.S.E.), Drew University, Madison, NJ

    Arnold L. Demain PhD

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© 2005 Humana Press Inc., Totowa, NJ

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Zengler, K., Paradkar, A., Keller, M. (2005). New Methods to Access Microbial Diversity for Small Molecule Discovery. In: Zhang, L., Demain, A.L. (eds) Natural Products. Humana Press. https://doi.org/10.1007/978-1-59259-976-9_12

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  • DOI: https://doi.org/10.1007/978-1-59259-976-9_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-383-1

  • Online ISBN: 978-1-59259-976-9

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