Abstract
Diabetes mellitus is characterized by fasting and postprandial hyperglycemia. Type 1 diabetes occurs secondary to autoimmune destruction of the insulin-secreting pancreatic β-cells, whereas type 2 diabetes results from a deficiency of insulin action secondary to a combination of insulin resistance and relative β-cell dysfunction. Familial clustering of type 1 and 2 diabetes has suggested a genetic contribution to the etiology of the diseases, but monozygotic twin and other studies have indicated that environmental factors also contribute to their etiology. Although relatively rare monogenic forms of diabetes have been described, type 1 and 2 diabetes are, in general, complex, polygenic diseases.
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Lowe, W.L. (2006). Diabetes Mellitus. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_32
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DOI: https://doi.org/10.1007/978-1-59259-963-9_32
Publisher Name: Humana Press
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