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Sarcoidosis

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Principles of Molecular Medicine

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Abstract

Sarcoidosis is a disease characterized by granulomatous inflammation in organs and tissues, which is believed to develop in genetically predisposed individuals following exposure to a triggering antigen. Although the etiology of sarcoidosis remains unproven, recent molecular investigations suggest that an immune response against mycobacterial and propionibacterial antigens may play a role in pathogensis. The immune response of sarcoidosis is characterized by a highly polarized Th1 cytokine profile elaborated by lymphocytes and macrophages within granulomas. Elucidation of the specific cytokine mediators of inflammation has led to better markers of disease activity as well as novel targets for new therapies.

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Selected References

  • Abe C, Iwai K, Mikami R, Hosoda Y. Frequent isolation of Propionibacterium acnes from sarcoidosis lymph nodes. Zentralbl Bakteriol Mikrobiol Hyg [A] 1984; 256(4):541–547

    CAS  Google Scholar 

  • Bachelez H, Senet P, Cadranel J, Kaoukhov A, Dubertret L. The use of tetracyclines for the treatment of sarcoidosis. Arch Dermatol 2001; 137:69–73

    PubMed  CAS  Google Scholar 

  • Baughman RP, Keeton D, Lower EE. Relationship between interleukin-8 and neutrophils in the BAL fluid of sarcoidosis. Sarcoidosis 1994; 11:S217–S220

    Google Scholar 

  • Baughman RP, Lower EE. Infliximab for refractory sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18:70–74

    PubMed  CAS  Google Scholar 

  • Baughman RP, Lower EE, du Bois RM. Sarcoidosis. Lancet 2003; 361: 1111–1118

    Article  PubMed  CAS  Google Scholar 

  • Baughman RP, Strohofer SA, Buchsbaum J, Lower EE. Release of tumor necrosis factor by alveolar macrophages of patients with sarcoidosis. J Lab Clin Med 1990; 115:36–42

    PubMed  CAS  Google Scholar 

  • Bocart D, Lecossier D, De Lassence A, Valeyre D, Battesti JP, Hance AJ. A search for mycobacterial DNA in granulomatous tissues from patients with sarcoidosis using the polymerase chain reaction. Am Rev RespirDis 1992; 145:1142–1148

    CAS  Google Scholar 

  • Cannone M, Vago L, Porini G, et al. Detection of mycobacterium tuberculosis DNA using nested polymerase chain reaction in lymph nodes with sarcoidosis,fixed in formalin and embedded in paraffin. Pathologica 1997; 89:512–516

    PubMed  CAS  Google Scholar 

  • du Bois RM, Goh N, McGrath D, Cullinan P. Is there a role for microorganisms in the pathogenesis of sarcoidosis? J Intern Med 2003; 253: 4–17

    Article  PubMed  Google Scholar 

  • Duncan MR, Berman B. Gamma interferon is the lymphokine and beta interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J Exp Med 1985;162:516–527

    Article  PubMed  CAS  Google Scholar 

  • Eishi Y, Suga M, Ishige I, et al. Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis. J Clin Microbiol 2002; 40:198–204

    Article  PubMed  CAS  Google Scholar 

  • el-Zaatari FA, Naser SA, Markesich DC, Kalter DC, Engstand L, Graham DY. Identification of Mycobacterium avium complex in sarcoidosis. J Clin Microbiol 1996; 34:2240–2245

    PubMed  CAS  Google Scholar 

  • Fidler HM, Rook GA, Johnson NM, McFadden J. Mycobacterium tuberculosis DNA in tissue affected by sarcoidosis. BMJ 1993; 306:546–549

    Article  PubMed  CAS  Google Scholar 

  • Gazouli M, Ikonomopoulos J, Trigidou R, Foteinou M, Kittas C, Gorgoulis V. Assessment of mycobacterial,propionibacterial,and human herpesvirus 8 DNA in tissues of greek patients with sarcoidosis. J Clin Microbiol 2002; 40:3060–3063

    Article  PubMed  CAS  Google Scholar 

  • Gerdes J, Richter E, Rusch-Gerdes S, et al. Mycobacterial nucleic acids in sarcoid lesions. Lancet 1992; 339:1536,1537

    Article  Google Scholar 

  • Ghossein RA, Ross DG, Salomon RN, Rabson AR. A search for mycobacterial DNA in sarcoidosis using the polymerase chain reaction. Am J Clin Pathol 1994; 101:733–737

    PubMed  CAS  Google Scholar 

  • Grosser M, Luther T, Muller J, et al. Detection of M.tuberculosis DNA in sarcoidosis: correlation with T-cell response. Lab Invest 1999; 79:775–784

    PubMed  CAS  Google Scholar 

  • Grunewald J, Janson CH, Eklund A, et al. Restricted V alpha 2.3 gene usage by CD4+T lymphocytes in bronchoalveolar lavage fluid from sarcoidosis patients correlates with HLA-DR3. Eur J Immunol 1992; 22:129–135

    Article  PubMed  CAS  Google Scholar 

  • Homma JY, Abe C, Chosa H, et al. Bacteriological investigation on biopsy specimens from patients with sarcoidosis. Jpn J Exp Med 1978; 48: 251–255

    PubMed  CAS  Google Scholar 

  • Hunninghake GW, Crystal RG. Pulmonary sarcoidosis: A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 1981; 305:429–434

    Article  PubMed  CAS  Google Scholar 

  • Ikonomopoulos JA, Gorgoulis VG, Zacharatos PV, et al. Multiplex polymerase chain reaction for the detection of mycobacterial DNA in cases of tuberculosis and sarcoidosis. Mod Pathol 1999 12: 854–862

    PubMed  CAS  Google Scholar 

  • Inoue Y, King TE Jr, Tinkle SS, Dockstader K, Newman LS. Human mast cell basic fibroblast growth factor in pulmonary fibrotic disorders. Am J Pathol 1996; 149:2037–2054

    PubMed  CAS  Google Scholar 

  • Ishige I, Usui Y, Takemura T, Eishi Y. Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis. Lancet 1999; 354:120–123

    Article  PubMed  CAS  Google Scholar 

  • Kaneko H, Yamada H, Mizuno S, et al. Role of tumor necrosis factoralpha in Mycobacterium-induced granuloma formation in tumor necrosis factor-alpha-deficient mice. Lab Invest 1999; 79:379–386

    PubMed  CAS  Google Scholar 

  • Katzenstein A-L. Katzenstein and Askin’s surgical pathology of nonneoplastic lung disease. In: Livolsi V, ed. Major Problems in Pathology. Volume 13. Philadelphia, PA: W.B. Saunders, 1997; pp.477

    Google Scholar 

  • Keane J, Gershon S, Wise RP, et al. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001; 345:1098–1104

    Article  PubMed  CAS  Google Scholar 

  • Klemen H, Husain AN, Cagle PT, Garrity ER, Popper HH. Mycobacterial DNA in recurrent sarcoidosis in the transplanted lung-a PCR-based study on four cases. Virchows Arch 2000; 436:365–369

    Article  PubMed  CAS  Google Scholar 

  • Li N, Bajoghli A, Kubba A, Bhawan J. Identification of mycobacterial DNA in cutaneous lesions of sarcoidosis. J Cutan Pathol 1999; 26: 271–278

    Article  PubMed  CAS  Google Scholar 

  • Limper AH, Colby TV, Sanders MS, Asakura S, Roche PC, DeRemee RA. Immunohistochemical localization of transforming growth factorbeta 1 in the nonnecrotizing granulomas of pulmonary sarcoidosis. Am J Respir Crit Care Med 1994; 149:197–204

    PubMed  CAS  Google Scholar 

  • Lisby G, Milman N, Jacobsen GK. Search for Mycobacterium paratuberculosis DNA in tissue from patients with sarcoidosis by enzymatic gene amplification. APMIS 1993; 101:876–878

    Article  PubMed  CAS  Google Scholar 

  • Moller DR, Chen ES. Genetic basis of remitting sarcoidosis: triumph of the trimolecular complex? Am J Respir Cell Mol Biol 2002; 27:391–395

    PubMed  CAS  Google Scholar 

  • Moller DR, Forman JD, Liu MC, et al. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol 1996; 156:4952–4960

    PubMed  CAS  Google Scholar 

  • Moller DR. Involvement of T cells and alterations in T cell receptors in sarcoidosis. Semin Respir Infect 1998; 13:174–183

    PubMed  CAS  Google Scholar 

  • Moller DR. Pulmonary fibrosis of sarcoidosis: new approaches, old ideas. Am J Respir Cell Mol Biol 2003; 29:S37–S41

    PubMed  CAS  Google Scholar 

  • Nakayama T, Hashimoto S, Amemiya E, Horie T. Elevation of plasmasoluble tumour necrosis factor receptors (TNF-R) in sarcoidosis. Clin Exp Immunol 1996; 104:318–324

    Article  PubMed  CAS  Google Scholar 

  • Nishiwaki T, Yoneyama H, Eishi Y, et al. Indigenous pulmonary Propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice. Am J Pathol 2004; 165:631–639

    PubMed  Google Scholar 

  • Ohchi T, Shijubo N, Kawabata I, et al. Polymorphism of Clara cell 10kD protein gene of sarcoidosis. Am J Respir Crit Care Med 2004; 169:180–186

    Article  PubMed  Google Scholar 

  • Ota M, Amakawa R, Uehira K, et al. Involvement of dendritic cells in sarcoidosis. Thorax 2004; 59:408–413

    Article  PubMed  CAS  Google Scholar 

  • Pesci A, Bertorelli G, Gabrielli M, Olivieri D. Mast cells in fibrotic lung disorders. Chest 1993; 103:989–996

    Article  PubMed  CAS  Google Scholar 

  • Pinkston P, Bitterman PB, Crystal RG. Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis. N Engl J Med 1983; 308:793–800

    Article  PubMed  CAS  Google Scholar 

  • Popper HH, Klemen H, Hoefler G, Winter E. Presence of mycobacterial DNA in sarcoidosis. Hum Pathol 1997; 28:796–800

    Article  PubMed  CAS  Google Scholar 

  • Popper HH, Winter E, Hofler G. DNA of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissue in tuberculosis and sarcoidosis detected by polymerase chain reaction. Am J Clin Pathol 1994; 101:738–741

    PubMed  CAS  Google Scholar 

  • Richter E, Greinert U, Kirsten D, et al. Assessment of mycobacterial DNA in cells and tissues of mycobacterial and sarcoid lesions. Am J Respir Crit Care Med 1996; 153:375–380

    PubMed  CAS  Google Scholar 

  • Robinson BW, McLemore TL, Crystal RG. Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis. J Clin Invest 1985; 75:1488–1495

    Article  PubMed  CAS  Google Scholar 

  • Rybicki BA, Iannuzzi MC, Frederick MM, et al. Familial aggregation of sarcoidosis. A case-control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med 2001; 164:2085–2091

    PubMed  CAS  Google Scholar 

  • Saboor SA, Johnson NM, McFadden J. Detection of mycobacterial DNA in sarcoidosis and tuberculosis with polymerase chain reaction. Lancet 1992; 339:1012–1015

    Article  PubMed  CAS  Google Scholar 

  • Sato H, Grutters JC, Pantelidis P, et al. HLA-DQB 1*0201: a marker for good prognosis in British and Dutch patients with sarcoidosis. Am J Respir Cell Mol Biol 2002; 27:406–412

    PubMed  CAS  Google Scholar 

  • Schurmann M, Reichel P, Muller-Myhsok B, Schlaak M, MullerQuernheim J, Schwinger E. Results from a genome-wide search for predisposing genes in sarcoidosis. Am J Respir Crit Care Med 2001; 164:840–846

    PubMed  CAS  Google Scholar 

  • Shigehara K, Shijubo N, Ohmichi M, et al. IL-12 and IL-18 are increased and stimulate IFN-gamma production in sarcoid lungs. J Immunol 2001; 166:642–649

    PubMed  CAS  Google Scholar 

  • Song Z, Marzilli L, Greenlee BM et al. Mycobacterial catalase-peroxidase is a tissue antigen and target of the adaptive immune response in systemic sarcoidosis. J Exp Med 2005; 201:755–767

    Article  PubMed  CAS  Google Scholar 

  • Thakker B, Black M, Foulis AK. Mycobacterial nucleic acids in sarcoid lesions. Lancet 1992; 339:1537

    Article  PubMed  CAS  Google Scholar 

  • Tomita H, Sato S, Matsuda R et al. Serum Lysozyme levels and clinical features of saroidosis. Lung 1999; 177:161–167

    Article  PubMed  CAS  Google Scholar 

  • Vokurka M, Lecossier D, du Bois RM, et al. Absence of DNA from mycobacteria of the M. tuberculosis complex in sarcoidosis. Am J Respir Crit Care Med 1997; 156:1000–1003

    PubMed  CAS  Google Scholar 

  • Wilsher ML, Menzies RE, Croxson MC. Mycobacterium tuberculosis DNA in tissues affected by sarcoidosis. Thorax 1998; 53: 871–874

    Article  PubMed  CAS  Google Scholar 

  • Yamada T, Eishi Y, Ikeda S, et al. In situ localization of Propionibacterium acnes DNA in lymph nodes from sarcoidosis patients by signal amplification with catalysed reporter deposition. J Pathol 2002; 198: 541–547

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC

    Kelly D. Chason

  2. Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC

    Stephen L.

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  1. Kelly D. Chason
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  2. Stephen L.
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Editors and Affiliations

  1. Department of Medicine, Division of Cardiology Carolina Cardiovascular Biology Center, University of North Carolina School of Medicine, Chapel Hill, NC

    Marschall S. Runge MD, PhD  & Cam Patterson MD  & 

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© 2006 Humana Press Inc.

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Chason, K.D., L., S. (2006). Sarcoidosis. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_29

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  • DOI: https://doi.org/10.1007/978-1-59259-963-9_29

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-202-5

  • Online ISBN: 978-1-59259-963-9

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