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Abstract

Chronic obstructive pulmonary disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible caused by a noxious agent. COPD is the fourth leading cause of mortality and affects more than 16 million people in the United States, a number that has increased about 40% since 1982. As COPD and other cigarette-related diseases become epidemic worldwide, the biology of emphysema is clearly complex and poorly understood with limited translation into effective pharmacotherapy.

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Selected References

  • Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA 1994; 272:1497–1505.

    Article  PubMed  CAS  Google Scholar 

  • Chapman H, Riese R, Shi G-P. Emerging roles for cysteine proteinases in tissue injury. Annu Rev Physiol 1997;59:63–88.

    Article  PubMed  CAS  Google Scholar 

  • D’Armiento J, Dalal SS, Okada Y, Berg RA, Chada K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 1992;71:955–961.

    Article  PubMed  CAS  Google Scholar 

  • Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Macrophage elastase is required for the development of emphysema induced by cigarette smoke in mice. Science 1997;277:2002–2004.

    Article  PubMed  CAS  Google Scholar 

  • Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000 106:1311–1319.

    PubMed  CAS  Google Scholar 

  • Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC. Chronic obstructive pulmonary disease surveillance-United States, 1971-2000. MMWR Surveill Summ 2000;51:1–16.

    Google Scholar 

  • Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 1997; 6:675–677.

    Article  Google Scholar 

  • Mecham RP, Davis EC. Elastic fiber structure and assembly. In: Yurchenko P, Birk D, Mecham R, eds. Extracellular Matrix Assembly and Structure. San Diego: Academic Press, 1994; pp. 281–314.

    Google Scholar 

  • Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (Gold) Workshop summary. Am J Respir Crit Care Med 2001;163:1256–1276.

    PubMed  CAS  Google Scholar 

  • Retamales I, Elliott WM, Meshi B, et al. Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med 2001;164:469–473.

    PubMed  CAS  Google Scholar 

  • Shapiro S. The macrophage in chronic obstruction pulmonary disease. Am J Respir Crit Care Med 2000;160(5 Pt 2):S29–S32.

    Google Scholar 

  • Stockley RA. Proteases and antiproteases. Novartis Found Symp 2000; 234:189–199; discussion 199-204.

    Article  Google Scholar 

  • Silverman EK. Hereditary pulmonary emphysema. In: Rimoin DL, Connor M, Pyeritz RE, Korf BR, Emery AE, eds. Emery and Rimoin’s Principles and Practice Of Medical Genetics. 4th ed., London: Churchill Livingstone, 2002.

    Google Scholar 

  • Wright JL. Emphysema: Concepts under change-a pathologist’s perspective. Mod Pathol 1995;8:873–880.

    PubMed  CAS  Google Scholar 

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© 2006 Humana Press Inc.

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Shapiro, S.D. (2006). Pulmonary Emphysema. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_23

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  • DOI: https://doi.org/10.1007/978-1-59259-963-9_23

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-202-5

  • Online ISBN: 978-1-59259-963-9

  • eBook Packages: MedicineMedicine (R0)

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