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Heart Failure

Emerging Concepts in Excitation-Contraction Coupling and β-Adrenoceptor Coupling

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Principles of Molecular Medicine

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Abstract

The process that begins contraction in the heart is known as excitation—contraction (E—C) coupling because it couples electrical signals on the membrane of the cardiac cell to activation of the myofilament and cross-bridge cycling. The cardiac action potential is produced by the coordinated interaction of many ion channels, which transduce physiological signals within and between cardiomyocytes. These cardiomyocytes are further regulated by a number of receptors that control the strength of the contraction on a beat-to-beat basis and their morphology in a chronic fashion. In heart failure, a number of steps in E—C coupling become abnormal. In this chapter, we will examine the role of these abnormalities in the development of heart failure.

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Authors and Affiliations

  1. Imperial College, National Heart and Lung Institute, London, UK

    Clive J. Lewis

  2. Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA

    Federica Del Monte

  3. Imperial College, National Heart and Lung Institute, London, UK

    Sian E. Harding & Roger J. Hajjar

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  1. Clive J. Lewis
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  2. Federica Del Monte
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  3. Sian E. Harding
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  4. Roger J. Hajjar
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Editor information

Editors and Affiliations

  1. Department of Medicine, Division of Cardiology Carolina Cardiovascular Biology Center, University of North Carolina School of Medicine, Chapel Hill, NC

    Marschall S. Runge MD, PhD  & Cam Patterson MD  & 

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© 2006 Humana Press Inc.

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Lewis, C.J., Monte, F.D., Harding, S.E., Hajjar, R.J. (2006). Heart Failure. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Medicine. Humana Press. https://doi.org/10.1007/978-1-59259-963-9_12

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  • DOI: https://doi.org/10.1007/978-1-59259-963-9_12

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