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Angiogenesis and Direct Myocardial Revascularization pp 37–64Cite as

Preclinical Models and Experience to Date

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

In the last decade, therapeutic angiogenesis in cardiovascular diseases has been extensively investigated using a variety of animal models. Recently, there have been great efforts to begin such research in human trials. There is still, however, an ongoing need for continued preclinical investigations to illuminate the complexity of angiogenic agents. Therapeutic modalities including autologous stem cell transplantation, targeted protein delivery, prolonged protein half-life, and various combination therapies are only some of the areas that require further investigation.

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Authors and Affiliations

  1. American Cardiovascular Research Institute, St. Joseph’s Hospital of Atlanta, Atlanta, GA

    Aysegul Yegin MD & Nicolas A. Chronos MD

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  1. Aysegul Yegin MD
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  2. Nicolas A. Chronos MD
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Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Boston, MA

    Roger J. Laham MD

  2. Brigham and Women’s Hospital, Boston, MA

    Donald S. Baim MD

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Yegin, A., Chronos, N.A. (2005). Preclinical Models and Experience to Date. In: Laham, R.J., Baim, D.S. (eds) Angiogenesis and Direct Myocardial Revascularization. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-934-9_3

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  • DOI: https://doi.org/10.1007/978-1-59259-934-9_3

  • Publisher Name: Humana Press

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