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Transcriptional Regulation of Angiogenesis

  • Chapter
Angiogenesis and Direct Myocardial Revascularization

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Until recently, the transcription factors necessary for regulating vascular development were largely unknown. This is in sharp contrast with other developmental processes, such as hematopoiesis and myogenesis, in which several cell- or tissue-specific transcription factors have been identified. Vascular development requires the differentiation of endothelial cells from pluripotent stem cells. Progress in identifying the molecular mechanisms underlying vascular development has lagged considerably, in large part the model systems for studying vascular blood vessel development are more limited. The identification of several vascular-specific genes involved in vasculogenesis and the genomic regulatory regions required for directing their expression over the past decade has facilitated the identification of the transcriptional mechanisms required for vascular-specific gene expression. Targeted disruption of additional transcription factors that have been associated with vascular defects led to the elucidation of a role for these factors in vascular development. Angiogenesis, the development of additional blood vessels from a primary vascular network, may recapitulate many of the molecular events occurring during vascular development.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

    Peter Oettgen MD

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  1. Peter Oettgen MD
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Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Boston, MA

    Roger J. Laham MD

  2. Brigham and Women’s Hospital, Boston, MA

    Donald S. Baim MD

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© 2005 Humana Press Inc., Totowa, NJ

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Oettgen, P. (2005). Transcriptional Regulation of Angiogenesis. In: Laham, R.J., Baim, D.S. (eds) Angiogenesis and Direct Myocardial Revascularization. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-934-9_2

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  • DOI: https://doi.org/10.1007/978-1-59259-934-9_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-153-0

  • Online ISBN: 978-1-59259-934-9

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