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Transmyocardial Laser Revascularization

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Angiogenesis and Direct Myocardial Revascularization

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Numerous patients with coronary artery disease have been successfully treated with conventional methods, such as coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI), but a significant and increasing number of patients have exhausted the ability to undergo these procedures repeatedly because of the diffuse nature of their coronary artery disease. As a result, they have chronic disabling angina that is often refractory to medical therapy. Transmyocardial laser revascularization (TMR) was developed to treat these patients. Although Mirhoseini et al. (1,2) and Okada et al. (3,4) pioneered the use of a laser to perform this type of revascularization in conjunction with CABG in the early 1980s, the use of a laser as sole therapy required advancements in the technology to establish its efficacy. Since then, more than 15,000 patients have been treated with TMR around the world and results from individual institutions, multicenter studies, and prospective randomized control trials have been reported (5–18).

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  1. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD

    Keith A. Horvath MD

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  1. Beth Israel Deaconess Medical Center, Boston, MA

    Roger J. Laham MD

  2. Brigham and Women’s Hospital, Boston, MA

    Donald S. Baim MD

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Horvath, K.A. (2005). Transmyocardial Laser Revascularization. In: Laham, R.J., Baim, D.S. (eds) Angiogenesis and Direct Myocardial Revascularization. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-934-9_13

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