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GPCR Interacting Proteins

Classes, Assembly, and Functions

  • Chapter
The G Protein-Coupled Receptors Handbook

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

The complex transduction of ligand stimulation events at G-protein coupled receptors (GPCRs) by heterotrimetric G proteins has long been appreciated. In addition to this, recent data shows that other protein interactions assist and can fine-tune cellular signals. Scientists have identified other membrane and intracellular proteins that interact, directly or indirectly, with GPCRs. In fact, 50 or more proteins are described in current literature as GPCR interactive proteins. GPCR interacting proteins act as modulators of ligand-evoked signals. Membrane associated or intracellular GPCR interacting proteins have critical roles in mediating: ligand recognition, optimization of signal transduction, trafficking, receptor clustering, and/or compartmentalization. This chapter reviews four aspects of the GPCR interacting protein literature: (a) methods for identifying GPCR interacting proteins; (b) interaction domains on the GPCR; (c) facilitation and fine-tuning of GPCR signaling events by interacting proteins; and (d) particular analysis of proteins that are μ opioid receptor (μOR) interactive. Although GPCR dimerization is viewed by many as a type of protein interaction between the GPCRs, dimer-related protein interactions will not be discussed; an alternate section of this book is devoted to dimerization.

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Author information

Authors and Affiliations

  1. Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Massachusetts

    Hongyan Wang PhD

  2. Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland

    Catherine B. Willmore PhD & Jia Bei Wang MD, PhD

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  1. Hongyan Wang PhD
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  2. Catherine B. Willmore PhD
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  3. Jia Bei Wang MD, PhD
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Editors and Affiliations

  1. Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY

    Lakshmi A. Devi PhD

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© 2005 Humana Press Inc., Totowa, NJ

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Wang, H., Willmore, C.B., Wang, J.B. (2005). GPCR Interacting Proteins. In: Devi, L.A. (eds) The G Protein-Coupled Receptors Handbook. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59259-919-6_9

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