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RGS Proteins

Orchestration of Multiple Signaling Pathways
  • Ryan W. Richman
  • María A. Diversé-Pierluissi
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

For several years, the model for the transduction of G protein-mediated signals consisted of three components: a heptahelical receptor, a heterotrimeric G protein, and an effector (1). The heptahelical receptor, which spans the membrane seven times, is coupled to a G protein complex consisting of an α-subunit in the guanosine-5′-diphosphate-bound form (α-GDP) and a βγ-dimer. Upon agonist binding to the receptor, a conformational change occurs in the G protein α-subunit, which leads to the release of the GDP and the binding to guanosine-5′-triphosphate (GTP). The α-GTP has lower affinity toward the βγ-dimer, releasing it from the G protein heterotrimer complex (Fig. 1) (1). Both α-GTP and βγ-dimer are known to regulate a wide range of effectors (2).

Keywords

Serum Response Element Tyrosine Kinase Pathway Heptahelical Receptor Protein Heterotrimer Complex Mammalian Gene Family 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Ryan W. Richman
    • 1
  • María A. Diversé-Pierluissi
    • 1
  1. 1.Department of Pharmacology and Biological ChemistryMount Sinai School of MedicineNew York

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