RGS Proteins

Orchestration of Multiple Signaling Pathways
  • Ryan W. Richman
  • María A. Diversé-Pierluissi
Part of the Contemporary Clinical Neuroscience book series (CCNE)


For several years, the model for the transduction of G protein-mediated signals consisted of three components: a heptahelical receptor, a heterotrimeric G protein, and an effector (1). The heptahelical receptor, which spans the membrane seven times, is coupled to a G protein complex consisting of an α-subunit in the guanosine-5′-diphosphate-bound form (α-GDP) and a βγ-dimer. Upon agonist binding to the receptor, a conformational change occurs in the G protein α-subunit, which leads to the release of the GDP and the binding to guanosine-5′-triphosphate (GTP). The α-GTP has lower affinity toward the βγ-dimer, releasing it from the G protein heterotrimer complex (Fig. 1) (1). Both α-GTP and βγ-dimer are known to regulate a wide range of effectors (2).


Serum Response Element Tyrosine Kinase Pathway Heptahelical Receptor Protein Heterotrimer Complex Mammalian Gene Family 
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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Ryan W. Richman
    • 1
  • María A. Diversé-Pierluissi
    • 1
  1. 1.Department of Pharmacology and Biological ChemistryMount Sinai School of MedicineNew York

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