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Thrombosis

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Essential Cardiology

Abstract

Thrombosis and hemostasis are similar processes, the former being pathologic and involving intravascular formation of aggregates of platelets and fibrin, and the latter resulting in the cessation of bleeding after external injury to the vasculature. While it is not clear that these processes involve precisely the same biochemical and biophysical events, they appear to be sufficiently similar to be considered as a single process that results in quite different structures owing to the local environment, either within a vessel or at the site of bleeding.

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References

  1. Nemerson Y. Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71:1 178]. Blood 198871:1–8.

    PubMed  CAS  Google Scholar 

  2. Edgington TS, Ruf W, Rehemtulla A, Mackman N. The molecular biology of initiation of coagulation by tissue factor. Curr Stud Hematol Blood Transfus 1991;58:15–21.

    PubMed  CAS  Google Scholar 

  3. Fuster V. Present concepts of coronary atherosclerosis-thrombosis, therapeutic implications and perspectives. Arch Mal Coeur Vaiss 1997;90 Spec No 6:41–47.

    PubMed  Google Scholar 

  4. Hsu TC, Shore SK, Seshsmma T, et al. Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene. J Biol Chem 1998;273:13,787–13,793.

    Article  PubMed  CAS  Google Scholar 

  5. Hu CJ, Baglia FA, Mills DC, et al. Tissue-specific expression of functional platelet factor XI is independent of plasma factor XI expression. Blood 1998;91:3800–3807.

    PubMed  CAS  Google Scholar 

  6. Gailani D, Broze GJ Jr. Factor XI activation in a revised model of blood coagulation. Science 1991;253:909–912.

    Article  PubMed  CAS  Google Scholar 

  7. Wildgoose P, Nemerson Y, Hansen LL, et al. Measurement of basal levels of factor VIIa in hemophilia A and B patients. Blood 1992;80:25–28.

    PubMed  CAS  Google Scholar 

  8. Morrissey JH. Plasma factor VIIa: measurement and potential clinical significance. Haemostasis 1996;26(Suppl 1):66–71.

    PubMed  CAS  Google Scholar 

  9. Banner DW, D’Arcy A, Chene C, et al. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor [see comments]. Nature 1996;380:41–46.

    Article  PubMed  CAS  Google Scholar 

  10. Nemerson Y, Repke D. Tissue factor accelerates the activation of coagulation factor VII: the role of a bifunctional coagulation cofactor. Thromb Res 1985;40:351–358.

    Article  PubMed  CAS  Google Scholar 

  11. Rao LV, Rapaport SI. Activation of factor VII bound to tissue factor: a key early step in the tissue factor pathway of blood coagulation. Proc Natl Acad Sci USA 1988;85:6687–6691.

    Article  PubMed  CAS  Google Scholar 

  12. Palabrica T, Lobb R, Furie BC, et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature 1992;359:848–851.

    Article  PubMed  CAS  Google Scholar 

  13. Esmon CT, Gu JM, Xu J, et al. Regulation and functions of the protein C anticoagulant pathway. Haematologica 1999;84:363–368.

    PubMed  CAS  Google Scholar 

  14. Bajzar L, Morser J, Nesheim M. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex. J Biol Chem 1996;271:16,603–16,608.

    Article  PubMed  CAS  Google Scholar 

  15. Heresbach D, Pagenault M, Gueret P, et al. Leiden factor V mutation in four patients with small bowel infarctions. Gastroenterology 1997;113:322–325.

    Article  PubMed  CAS  Google Scholar 

  16. Rosendaal FR. Thrombosis in the young: epidemiology and risk factors. A focus on venous thrombosis. Thromb Haemost 1997;78:1–6.

    PubMed  CAS  Google Scholar 

  17. Eskandari MK, Bontempo FA, Hassett AC, et al. Arterial thromboembolic events in patients with the factor V Leiden mutation. Am J Surg 1998;176:122–125.

    Article  PubMed  CAS  Google Scholar 

  18. Heijmans BT, Westendorp RG, Knook DL, et al. The risk of mortality and the factor V Leiden mutation in a population-based cohort. Thromb Haemost 1998;80:607–609.

    PubMed  CAS  Google Scholar 

  19. Coller BS, Owen J, Jesty J, et al. Deficiency of plasma protein S, protein C, or antithrombin III and arterial thrombosis. Arteriosclerosis 1987;7:456–462.

    PubMed  CAS  Google Scholar 

  20. Bajzar L, Nesheim M, Morser J, Tracy PB. Both cellular and soluble forms of thrombomodulin inhibit fibrinolysis by potentiating the activation of thrombin-activable fibrinolysis inhibitor. J Biol Chem 1998;273:2792–2798.

    Article  PubMed  CAS  Google Scholar 

  21. Broze GJ Jr, Miletich JP. Characterization of the inhibition of tissue factor in serum. Blood 1987;69:150–155.

    PubMed  Google Scholar 

  22. Rapaport SI. The extrinsic pathway inhibitor: a regulator of tissue factor-dependent blood coagulation. Thromb Haemost 1991;66:6–15.

    PubMed  CAS  Google Scholar 

  23. Huang ZF, Higuchi D, Lasky N, Broze GJ Jr. Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood 1997;90:944–951.

    PubMed  CAS  Google Scholar 

  24. Rosenberg RD. Biochemistry of heparin antithrombin interactions, and the physiologic role of this natural anticoagulant mechanism. Am J Med 1989;87:2S–9S.

    Article  PubMed  CAS  Google Scholar 

  25. Thompson SG, Fechtrup C, Squire E, et al. Antithrombin III and fibrinogen as predictors of cardiac events in patients with angina pectoris. Arterioscler Thromb Vasc Biol 1996;16:357–362.

    PubMed  CAS  Google Scholar 

  26. Geppert A, Graf S, Beckmann R, et al. Concentration of endogenous tPA antigen in coronary artery disease: relation to thrombotic events, aspirin treatment, hyperlipidemia, and multivessel disease. Arterioscler Thromb Vasc Biol 1998;18:1634–1642.

    PubMed  CAS  Google Scholar 

  27. Zhu Y, Carmeliet P, Fay WP. Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance. Circulation 1999;99:3050–3055.

    PubMed  CAS  Google Scholar 

  28. Cushman M, Lemaitre RN, Kuller LH, et al. Fibrinolytic activation markers predict myocardial infarction in the elderly. The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 1999;19:493–498.

    PubMed  CAS  Google Scholar 

  29. Rosendaal FR, Varekamp I, Smit C, et al. Mortality and causes of death in Dutch haemophiliacs, 1973-1986. Br J Haematol 1989;71:71–76.

    PubMed  CAS  Google Scholar 

  30. Salomon O, Steinberg DM, Dardik R, et al. Inherited factor XI deficiency confers no protection against acute myocardial infarction. J Thromb Haemost 2003;1:658–661.

    Article  PubMed  CAS  Google Scholar 

  31. Zeldis SM, Nemerson Y, Pitlick FA, Lentz TL. Tissue factor (thromboplastin): localization to plasma membranes by peroxidase-conjugated antibodies. Science 1972;175:766–768.

    Article  PubMed  CAS  Google Scholar 

  32. Wilcox JN, Smith KM, Schwartz SM, Gordon D. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 1989;86:2839–2843.

    Article  PubMed  CAS  Google Scholar 

  33. Thiruvikraman SV, Guha A, Roboz J, et al. In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X. Lab Invest 1996;75:451–461.

    PubMed  CAS  Google Scholar 

  34. Annex BH, Denning SM, Channon KM, et al. Differential expression of tissue factor protein in directional atherectomy specimens from patients with stable and unstable coronary syndromes. Circulation 1995;91:619–622.

    PubMed  CAS  Google Scholar 

  35. Marmur JD, Thiruvikraman SV, Fyfe BS, et al. Identification of active tissue factor in human coronary atheroma. Circulation 1996;94:1226–1232.

    PubMed  CAS  Google Scholar 

  36. Giesen PL, Rauch U, Bohrmann B, et al. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci USA 1999;96:2311–2315.

    Article  PubMed  CAS  Google Scholar 

  37. Maynard JR, Heckman CA, Pitlick FA, Nemerson Y. Association of tissue factor activity with the surface of cultured cells. J Clin Invest 1975;55:814–824.

    PubMed  CAS  Google Scholar 

  38. Bach R, Rifkin DB. Expression of tissue factor procoagulant activity: regulation by cytosolic calcium. Proc Natl Acad Sci USA 1990;87:6995–6999.

    Article  PubMed  CAS  Google Scholar 

  39. Le DT, Rapaport SI, Rao LV. Relations between factor VIIa binding and expression of factor VIIa/tissue factor catalytic activity on cell surfaces. J Biol Chem 1992;267:15,447–15,454.

    PubMed  CAS  Google Scholar 

  40. Schecter AD, Giesen PL, Taby O, et al. Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation. J Clin Invest 1997;100:2276–2285.

    Article  PubMed  CAS  Google Scholar 

  41. Bach RR, Moldow CF. Mechanism of tissue factor activation on HL-60 cells. Blood 1997;89:3270–3276.

    PubMed  CAS  Google Scholar 

  42. Carrozza JP Jr, Baim DS. Complications of directional coronary atherectomy: incidence, causes, and management. Am J Cardiol 1993;72:47E–54E.

    Article  PubMed  Google Scholar 

  43. Losordo DW, Rosenfield K, Pieczek A, et al. How does angioplasty work? Serial analysis of human iliac arteries using intravascular ultrasound. Circulation 1992;86:1845–1858.

    PubMed  CAS  Google Scholar 

  44. Nath FC, Muller DW, Ellis SG, et al. Thrombosis of a flexible coil coronary stent: frequency, predictors and clinical outcome. J Am Coll Cardiol 1993;21:622–627.

    Article  PubMed  CAS  Google Scholar 

  45. Marmur JD, Rossikhina M, Guha A, et al. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J Clin Invest 1993;91:2253–2259.

    PubMed  CAS  Google Scholar 

  46. Pawashe AB, Golino P, Ambrosio G, et al. A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries. Circ Res 1994;74:56–63.

    PubMed  CAS  Google Scholar 

  47. Speidel CM, Eisenberg PR, Ruf W, et al. Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits. Circulation 1995;92:3323–3330.

    PubMed  CAS  Google Scholar 

  48. Speidel CM, Thornton JD, Meng YY, et al. Procoagulant activity on injured arteries and associated thrombi is mediated primarily by the complex of tissue factor and factor VIIa. Coron Artery Dis 1996;7:57–62.

    PubMed  CAS  Google Scholar 

  49. Gertz SD, Fallon JT, Gallo R, et al. Hirudin reduces tissue factor expression in neointima after balloon injury in rabbit femoral and porcine coronary arteries. Circulation 1998;98:580–587.

    PubMed  CAS  Google Scholar 

Recommended Reading

  1. Belting M, Dorrell MI, Sandgren S, et al. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 2004;10:502–509.

    Article  PubMed  CAS  Google Scholar 

  2. Bogdanov VY, Balasubramanian V, Hathcock J, et al. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med 2003;9:458–462.

    Article  PubMed  CAS  Google Scholar 

  3. Degen JL. Genetic interactions between the coagulation and fibrinolytic systems. Thromb Haemost 2001;86:130–137.

    PubMed  CAS  Google Scholar 

  4. Mackman N. The role of the tissue factor-thrombin pathway in cardiac ischemia-reperfusion injury. Semin Vasc Med 2003;3:193–198.

    Article  PubMed  Google Scholar 

  5. Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 2004;24:1015–1022.

    Article  PubMed  CAS  Google Scholar 

  6. Ruf W, Dorfleutner A, Riewald M. Specificity of coagulation factor signaling. J Thromb Haemost 2003;1:1495–1503.

    Article  PubMed  CAS  Google Scholar 

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© 2005 Humana Press Inc., Totowa, NJ

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Nemerson, Y., Taubman, M.B. (2005). Thrombosis. In: Rosendorff, C. (eds) Essential Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-918-9_5

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  • DOI: https://doi.org/10.1007/978-1-59259-918-9_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-370-1

  • Online ISBN: 978-1-59259-918-9

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