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Platelet Function Under Flow

  • Chapter
Platelet Function

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

As vertebrates have evolved high-pressure, high-flow circulatory systems, an extraordinarily effective hemostatic system has developed alongside to protect these organisms from hemorrhage. More than a century’s worth of evidence indicates that platelets are the blood cells chiefly responsible for maintaining hemostasis and causing thrombosis. Platelets are geared to monitor vascular integrity and effect hemostasis in the arterial circulation, as injuries to arteries (rather than veins) are much more likely to result in circulatory collapse and death. Furthermore, deployment of the hemostatic mechanism in the setting of vascular disease—particularly that caused by atherosclerosis—is largely responsible for the tremendous disease burden associated with vascular disease, being the culminating event in myocardial infarction and stroke. In this chapter, we review the characteristics of blood flow that influence platelet function and the cellular and molecular determinants that allow the platelets to carry out their hemostatic functions under flow.

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Authors and Affiliations

  1. Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX

    José A. López MD, Ian del Conde MD & Jing-Fei Dong MD, PhD

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  1. José A. López MD
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  2. Ian del Conde MD
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  3. Jing-Fei Dong MD, PhD
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Editors and Affiliations

  1. Department of Cardiology, St. Vincent’s University Hospital, Dublin, Ireland

    Martin Quinn MB BCh BAO, PhD

  2. University College Dublin, Dublin, Ireland

    Desmond Fitzgerald MD, FRCPI, FESC, AAP (Vice President of Research) (Vice President of Research)

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© 2005 Humana Press Inc., Totowa, NJ

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López, J.A., del Conde, I., Dong, JF. (2005). Platelet Function Under Flow. In: Quinn, M., Fitzgerald, D. (eds) Platelet Function. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-917-2_9

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  • DOI: https://doi.org/10.1007/978-1-59259-917-2_9

  • Publisher Name: Humana Press

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