Abstract
Elevation of lung capillary pressure is a frequent clinical consequence of left-sided heart disease and characteristically results in the formation not only of pulmonary edema, but also of inflammatory reactions in the lung. These processes are largely attributable to mechano-induced second-messenger responses in lung capillary endothelial cells. Pressure- and stretch-induced mobilization of intra- and extracellular calcium mediates an increase in capillary permeability, thus contributing to pulmonary edema formation. In addition, endothelial calcium signaling promotes the exocytosis of endothelial Weibel-Palade bodies and, in consequence, vascular expression of P-selectin, thus initiating the sequestration of circulating leukocytes.
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References
Wagner, P. D., Gale, G. E., Moon, R. E., Torre-Bueno, J. R., Stolp, B. W., Saltzman, H. A. (1986) Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J. Appl. Physiol. 61, 260–270
Maggiorini, M., Melot, C., Pierre, S., et al. (2001) High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation 103, 2078–2083
Pabst, R. and Tschernig, T. (2002) Perivascular capillaries in the lung: an important but neglected vascular bed in immune reactions? J. Allergy Clin. Immunol. 110, 209–214.
B/:artsch, P. (1997) High altitude pulmonary edema. Respiration 64, 435–443
Audi, S. H., Dawson, C. A., Rickaby, D. A., and Linehan, J. H. (1991) Localization of the sites of pulmonary vasomotion by use of arterial and venous occlusion. J. Appl. Physiol. 70, 2126–2136.
West, J. B. (2000) Pulmonary capillary stress failure. J. Appl. Physiol. 89, 2483–2489
Parker, J. C. and Ivey, C. L. (1997) Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lung. J. Appl. Physiol. 83, 1962–1967
Minnear, F. L., Barie, P. S., and Malik, A. B. (1983) Effects of transient pulmonary hypertension on pulmonary vascular permeability. J. Appl. Physiol. 55, 983–989
Bhattacharya, J., Nakahara, K., and Staub, N. C. (1980) Effect of pulmonary blood flow in the isolated perfused dog lung lobe. J. Appl. Physiol. 48, 444–449.
Gotoh, N., Kambara, K., Jiang, X. W., et al. (2000) Apoptosis in microvascular endothelial cells of perfused rabbit lungs with acute hydrostatic edema. J. Appl. Physiol. 88, 518–526.
Saldias, F. J., Azzam, Z. S., Ridge, K. M., et al. (2001) Alveolar fluid reabsorption is impaired by increased atrial pressures in rats. Am. J. Physiol. Lung Cell Mol. Physiol. 281, L591–L597.
Kuebler, W. M., Parthasarathi, K., Wang, P. M., and Bhattacharya, J. (2000) A novel signaling mechanism between gas and blood compartments of the lung. J. Clin. Invest. 105, 905–913.
Ying, X., Minamiya, Y., Fu, C., and Bhattacharya, J. (1996) Ca2+ waves in lung capillary endothelium. Circ. Res. 79, 898–908.
Naruse, K. and Sokabe, M. (1993) Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells. Am. J. Physiol. 264, C1037–C1044.
Kohler, R., Distler, A., and Hoyer, J. (1998) Pressure-activated cation channel in intact rat endocardial endothelium. Cardiovasc. Res. 38, 433–440.
Kuebler, W. M., Ying, X., and Bhattacharya, J. (2002) Pressure-induced endothelial Ca2+ oscillations in lung capillaries. Am. J. Physiol. Lung Cell Mol. Physiol. 282, L917–L923.
Rosales, O. R., Isales, C. M., Barrett, P. Q., Brophy, C., and Sumpio, B. E. (1997) Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools. Biochem. J. 326, 385–392.
Monck, J. R. and Fernandez, J. M. (1996) The fusion pore and mechanisms of biological membrane fusion. Curr. Opin. Cell Biol. 8, 524–533.
Betz, W. J. and Bewick, G. S. (1992) Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction. Science 255, 200–203.
Smith, C. B. and Betz, W. J. (1996) Simultaneous independent measurement of endocytosis and exocytosis. Nature 380, 531–534.
Kuebler, W. M., Ying, X., Singh, B., Issekutz, A. C., and Bhattacharya, J. (1999) Pressure is pro-inflammatory in lung venular capillaries. J. Clin. Invest. 104, 495–502.
Bless, N. M., Tojo, S. J., Kawarai, H., et al. (1998) Differing patterns of P-selectin expression in lung injury. Am. J. Pathol. 153, 1113–1122.
Kuebler, W. M., Kuhnle, G. E. H., Groh, J., and Goetz, A. E. (1997) Contribution of selectins to sequestration of leukocytes in pulmonary microvessels by intravital microscopy in rabbits. J. Physiol. 501, 375–386.
Mulligan, M. S., Polley, M. J., Bayer, R. J., Nunn, M. F., Paulson, J. C., and Ward, P. A. (1992) Neutrophil dependent lung injury. Requirement for P-selectin (GMP-140). J. Clin. Invest. 90, 1600–1607.
Moore, T. M., Khimenko, P., Adkins, W. K., Miyasaka, M., and Taylor, A. E. (1995) Adhesion molecules contribute to ischemia and reperfusion-induced injury in the isolated rat lung. J. Appl. Physiol. 78, 2245–2252.
Kuebler, W. M., Borges, J., Sckell, A., et al. (2000) Role of L-selectin in leukocyte sequestration in lung capillaries in a rabbit model of endotoxemia. Am. J. Respir. Crit. Care Med. 161, 36–43.
Kuebler, W. M. and Goetz, A. E. (2002) The marginated pool. Eur. Surg. Res. 34, 92–100.
Sakamaki, F., Kyotani, S., Nagaya, N., et al. (2000) Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy. Circulation 102, 2720–2725.
Geppert, A., Zorn, G., Heinz, G., Huber, K., and Siostrzonek, P. (2001) Soluble selectins in the pulmonary and systemic circulation in acute cardiogenic and non-cardiogenic pulmonary failure. Intensive Care Med. 27, 521–527.
Nakos, G., Pneumatikos, J., Tsangaris, I., Tellis, C., and Lekka, M. (1997) Proteins and phospholipids in BAL from patients with hydrostatic pulmonary edema. Am. J. Respir. Crit. Care Med. 155, 945–951.
Kubo, K., Hanaoka, M., Hayano, T., et al. (1998) Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema. Respir. Physiol. 111, 301–310.
De Pasquale, C. G., Arnolda, L. F., Doyle, I. R., Grant, R. L., Aylward, P. E., and Bersten, A. D. (2003) Prolonged alveolocapillary barrier damage after acute cardiogenic pulmonary edema. Crit. Care Med. 31, 1060–1067.
Wang, P. M., Fujita, E., and Bhattacharya, J. (2002) Vascular regulation of type II cell exocytosis. Am. J. Physiol. Lung Cell Mol. Physiol. 282, L912–L916.
Kuebler, W. M., Uhlig, U., Goldmann, T., et al. (2003) Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ. Am. J. Respir. Crit. Care Med. 168, 1391–1398.
Ichimura, H., Parthasarathi, K., Quadri, S., Issekutz, A. C., and Bhattacharya, J. (2003) Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries. J. Clin. Invest. 111, 691–699.
Dschietzig, T., Richter, C., Bartsch, C., et al. (2001) Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium. Biochem. Biophys. Res. Commun. 289, 245–251.
Fisslthaler, B., Popp, R., Michaelis, U. R., Kiss, L., Fleming, I., and Busse, R. (2001) Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase. Hypertension 38, 1427–1432.
Okada, M., Matsumori, A., Ono, K., et al. (1998) Cyclic stretch upregulates production of interleukin-8 and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 18, 894–901.
Acevedo, A. D., Bowser, S. S., Gerritsen, M. E., and Bizios, R. (1993) Morphological and proliferative responses of endothelial cells to hydrostatic pressure: role of fibroblast growth factor. J. Cell Physiol. 157, 603–614.
Iba, T., Shin, T., Sonoda, T., Rosales, O., and Sumpio, B. E. (1991) Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. J. Surg. Res. 50, 457–460.
Sumpio, B. E., Widmann, M. D., Ricotta, J., Awolesi, M. A., and Watase, M. (1994) Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells. J. Cell Physiol. 158, 133–139.
Shin, H. Y., Gerritsen, M. E., and Bizios, R. (2002) Regulation of endothelial cell proliferation and apoptosis by cyclic pressure. Ann. Biomed. Eng. 30, 297–304.
Du, W., Mills, I., and Sumpio, B. E. (1995) Cyclic strain causes heterogeneous induction of transcription factors, AP1, CRE binding protein and NF-.B, in endothelial cells: species and vascular bed diversity. J. Biomech. 28, 1485–1491.
Naruse, K., Sai, X., Yokoyama, N., and Sokabe, M. (1998) Uni-axial cyclic stretch induces c-src activation and translocation in human endothelial cells via SA channel activation. FEBS Lett. 441, 111–115.
Hishikawa, K. and Luscher, T. F. (1997) Pulsatile stretch stimulates superoxide production in human aortic endothelial cells. Circulation 96, 3610–3616.
Letsou, G. V., Rosales, O., Maitz, S., Vogt, A., and Sumpio, B. E. (1990) Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. J. Cardiovasc. Surg. 31, 634–639.
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Kuebler, W.M. (2005). Pressure-Induced Inflammatory Signaling in Lung Endothelial Cells. In: Bhattacharya, J. (eds) Cell Signaling in Vascular Inflammation. Humana Press. https://doi.org/10.1007/978-1-59259-909-7_8
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DOI: https://doi.org/10.1007/978-1-59259-909-7_8
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