Abstract
The excitatory amino acids glutamate and aspartate, acting on glutamate receptors, exert important physiological functions in the central nervous system. But overactivation of these receptors can produce neuronal cell injury and death. Recent studies show that the glutamate agonist N-methyl-D-aspartate (NMDA) can trigger acute lung injury (ALI), manifested by high-permeability pulmonary edema, and that NMDA receptor subtypes are expressed in normal rat lung. These findings suggest that glutamate signaling may be involved in the pathogenesis of ALI and, as such, may be a novel target for the prevention or attenuation of this condition.
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© 2005 Humana Press Inc., Totowa, NJ
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Said, S.I. (2005). Glutamate Receptor Activation in the Pathogenesis of Acute Lung Injury. In: Bhattacharya, J. (eds) Cell Signaling in Vascular Inflammation. Humana Press. https://doi.org/10.1007/978-1-59259-909-7_6
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DOI: https://doi.org/10.1007/978-1-59259-909-7_6
Publisher Name: Humana Press
Print ISBN: 978-1-58829-525-5
Online ISBN: 978-1-59259-909-7
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