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Chemical Dissection of Brain Glucoregulatory Circuitry

  • Chapter
Molecular Neurosurgery With Targeted Toxins

Abstract

Glucose is the essential substrate for brain energy metabolism (1). Although glycogen, the major storage form of glucose, contributes dynamically to brain energy metabolism, it is present in very limited quantities (2). Thus, the brain requires continuous delivery of glucose by the blood. Clearly, then, the control of blood glucose is of fundamental importance for brain metabolism. Work in our laboratory has focused on the neural organization of controls that maintain blood glucose concentrations. The immunotoxin, antidopamine β-hydroxylase (anti-DβH) conjugated to saporin (anti-DβH-sap) (3–7), has been an invaluable tool for establishing the importance of hindbrain catecholamine neurons for coordinated arousal of critical behavioral, autonomic, and neuroendocrine responses to glucose deficit. The goal of this review is to describe our use of anti-DβH-sap in demonstrating the essential roles of hindbrain catecholamine neurons in glucoregulation.

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Authors and Affiliations

  1. Programs in Neuroscience, Washington State University, Pullman, WA

    Sue Ritter, Thu T. Dinh & Kishor Bugarith

  2. Programs in Neuroscience, University of Southern California, Los Angeles, CA

    Dawna M. Salter

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  1. Sue Ritter
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  2. Thu T. Dinh
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Editors and Affiliations

  1. Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  3. Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN

    Ronald G. Wiley MD, PhD

  4. Advanced Targeting Systems, San Diego, CA

    Douglas A. Lappi PhD (President and Chief Scientific Officer) (President and Chief Scientific Officer)

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Ritter, S., Dinh, T.T., Bugarith, K., Salter, D.M. (2005). Chemical Dissection of Brain Glucoregulatory Circuitry. In: Wiley, R.G., Lappi, D.A. (eds) Molecular Neurosurgery With Targeted Toxins. Humana Press. https://doi.org/10.1007/978-1-59259-896-0_8

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  • DOI: https://doi.org/10.1007/978-1-59259-896-0_8

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