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Ribosome-Inactivating Proteins

  • Chapter
Molecular Neurosurgery With Targeted Toxins

Abstract

The designation of ribosome-inactivating proteins (RIPs; reviews in refs. 1–4) has been applied to plant proteins that enzymatically damage ribosomes in a catalytic manner, thus inhibiting protein synthesis (Table 1). The first identified RIPs were two potent toxins, known for more than a century: ricin, from the seeds of Ricinus communis, and abrin, from the seeds of Abrus precatorius.

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Authors and Affiliations

  1. Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy

    Fiorenzo Stirpe MD

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  1. Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  3. Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN

    Ronald G. Wiley MD, PhD

  4. Advanced Targeting Systems, San Diego, CA

    Douglas A. Lappi PhD (President and Chief Scientific Officer) (President and Chief Scientific Officer)

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Stirpe, F. (2005). Ribosome-Inactivating Proteins. In: Wiley, R.G., Lappi, D.A. (eds) Molecular Neurosurgery With Targeted Toxins. Humana Press. https://doi.org/10.1007/978-1-59259-896-0_2

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