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Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons

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Molecular Neurosurgery With Targeted Toxins

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Abstract

Lectins are carbohydrate-binding proteins that recognize distinct oligosaccharide moieties of glycoproteins and glycolipids. In vertebrates, endogenous lectins serve a variety of functions, including cell adhesion, cell recognition, signal transduction, and endocytosis, in both neuronal and nonneuronal cells (1–5). A role for cell surface carbohydrate recognition has been described in processes, such as fertilization, development, leukocyte homing, and the innate immune response (1,2). Among the known classes of vertebrate carbohydrate-binding proteins are some cytokines (e.g., interleukin 1β [IL-1β]) and growth factors, which possess a receptor-binding domain and a carbohydrate recognition domain (4,5).

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Author information

Authors and Affiliations

  1. Deparment of Veterinary PathoBiology, University of Minnesota, St. Paul, MN

    Lucy Vulchanova

  2. Department of Neuroscience, University of Minnesota, Minneapolis, MN

    Christopher N. Honda

Authors
  1. Lucy Vulchanova
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  2. Christopher N. Honda
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Editor information

Editors and Affiliations

  1. Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN

    Ronald G. Wiley MD, PhD

  3. Neurology Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN

    Ronald G. Wiley MD, PhD

  4. Advanced Targeting Systems, San Diego, CA

    Douglas A. Lappi PhD (President and Chief Scientific Officer) (President and Chief Scientific Officer)

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© 2005 Humana Press Inc., Totowa, NJ

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Vulchanova, L., Honda, C.N. (2005). Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons. In: Wiley, R.G., Lappi, D.A. (eds) Molecular Neurosurgery With Targeted Toxins. Humana Press. https://doi.org/10.1007/978-1-59259-896-0_12

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  • DOI: https://doi.org/10.1007/978-1-59259-896-0_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-199-8

  • Online ISBN: 978-1-59259-896-0

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