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Advanced Magnetic Resonance Imaging in Leukodystrophies

  • Chapter
Book cover Bioimaging in Neurodegeneration

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Advanced magnetic resonance (MR) techniques, namely MR spectroscopy and perfusion MR imaging, have provided the researcher with new tools for evaluating leukodystrophies. They have allowed for better characterization of diseases, improved sensitivity of detection, and a means of tracking brain metabolites and perfusion in vivo to monitor therapy or disease progression. In some cases, these techniques also allow for the specific diagnosis of certain abnormalities. Evaluation of leukodystrophies with MR spectroscopy has advanced from the simple observation of metabolic derangements and correlation to pathophysiology to the prognostication of patient clinical outcome and the in vivo tracking of metabolic abnormalities after therapeutic intervention. We aim to describe how these technologies can aid the clinician in the preventative, diagnostic, and treatment schemes in these diseases.

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Authors and Affiliations

  1. Department of Radiology, NYU Medical Center, New York, NY

    Edwin Y. Wang MD & Meng Law MD, FRACR

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  1. Edwin Y. Wang MD
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  2. Meng Law MD, FRACR
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Editors and Affiliations

  1. Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY

    Patricia A. Broderick PhD

  2. Department of Neurology, New York University School of Medicine, New York, NY

    Patricia A. Broderick PhD  & Edwin H. Kolodny MD  & 

  3. NYU Comprehensive Epilepsy Center, New York, NY

    Patricia A. Broderick PhD

  4. Department of Chemistry and Physical Sciences, Pace University, Pleasantville, NY

    David N. Rahni PhD

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Wang, E.Y., Law, M. (2005). Advanced Magnetic Resonance Imaging in Leukodystrophies. In: Broderick, P.A., Rahni, D.N., Kolodny, E.H. (eds) Bioimaging in Neurodegeneration. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59259-888-5_21

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