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Pyramidal Tract Involvement in Adult Krabbe’s Disease

Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy Abnormalities

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Bioimaging in Neurodegeneration

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

In the last few years, the adult onset of globoid cell leukodystrophy or Krabbe disease has been recognized. A few authors have described an association of progressive spastic paraparesis and selective involvement of the corticospinal tracts in adult patients with deficiency of galactocerebrosidase, the Krabbe disease-related enzyme. This phenotypic expression of the disease should be considered in the differential diagnosis of spastic paraparesis. Magnetic resonance imaging may offer the clues for the recognition of this disorder. Proton MR spectroscopy may be useful in quantifying the damage to the corticospinal tract.

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Author information

Authors and Affiliations

  1. Department of Neuroradiology, Instituto Nazionale Neurologico “C. Besta”, Milan, Italy

    Laura Farina MD, Alberto Bizzi MD & Mario Savoiardo MD

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  1. Laura Farina MD
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  2. Alberto Bizzi MD
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  3. Mario Savoiardo MD
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Editor information

Editors and Affiliations

  1. Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY

    Patricia A. Broderick PhD

  2. Department of Neurology, New York University School of Medicine, New York, NY

    Patricia A. Broderick PhD  & Edwin H. Kolodny MD  & 

  3. NYU Comprehensive Epilepsy Center, New York, NY

    Patricia A. Broderick PhD

  4. Department of Chemistry and Physical Sciences, Pace University, Pleasantville, NY

    David N. Rahni PhD

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© 2005 Humana Press Inc., Totowa, NJ

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Farina, L., Bizzi, A., Savoiardo, M. (2005). Pyramidal Tract Involvement in Adult Krabbe’s Disease. In: Broderick, P.A., Rahni, D.N., Kolodny, E.H. (eds) Bioimaging in Neurodegeneration. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59259-888-5_19

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