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Portal Hypertension pp 85–97Cite as

Hepatic Hemodynamics in Portal Hypertension

Compliance, Hepatic Arterial Buffer Response, Hepatorenal Syndrome, and Liver Regeneration

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Part of the book series: Clinical Gastroenterology ((CG))

Abstract

This chapter will discuss some consequences of the hepatic hemodynamic disturbances that accompany portal hypertension. Fibrosis or other mechanisms that lead to a restriction of blood flow through the liver have enormous consequences to the entire cardiovascular system, endocrine processing system, and metabolic homeostasis in general. Many systems have evolved to compensate for the disturbances that result from portal hypertension but some regulatory systems result in a worsening of homeostasis as a result of confusion at the afferent end of the signaling process. For example, does the liver respond to a decrease in portal blood flow the same if the decrease is caused by vasoconstriction of the superior mesenteric artery and subsequent reduction in intestinal blood flow as it does if blood flow to the hepatic parenchymal cells is reduced because of portacaval shunt formation? This chapter represents a conceptual focus on our own areas of expertise with no attempt to provide a detailed literature review. Although the references arc few, more detailed references are available in the cited reviews and original articles. The approach taken is to evaluate the effects of increases and decreases in intra-hepatic portal flow on four vital hepatic areas: the hepatic blood reservoir, hepatic arterial blood flow, the hepatorenal reflex, and liver cell mass.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada

    W. Wayne Lautt & Zhi Ming

Authors
  1. W. Wayne Lautt
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  2. Zhi Ming
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, Virginia Commonwealth Medical Center, Richmond, VA

    Arun J. Sanyal MBBS, MD

  2. GI Research Unit, Mayo Clinic, Rochester, MN

    Vijay H. Shah MD

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© 2005 Humana Press Inc., Totowa, NJ

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Lautt, W.W., Ming, Z. (2005). Hepatic Hemodynamics in Portal Hypertension. In: Sanyal, A.J., Shah, V.H. (eds) Portal Hypertension. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-59259-885-4_6

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  • DOI: https://doi.org/10.1007/978-1-59259-885-4_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-386-2

  • Online ISBN: 978-1-59259-885-4

  • eBook Packages: MedicineMedicine (R0)

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