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Assessment of Ventricular Repolarization From Body-Surface ECGs in Humans

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Abstract

In 1887, the first recording of electrical activity of the human heart was done using Waller’s capillary meter. The recorded signal included four waves called A, B, C, and D. Einthoven mathematically modified this signal to correct the inertia associated with the movement of the mercury column in the capillary electrometer. To avoid confusion with Waller’s recording, Einthoven named the five identified deflections P, Q, R, S, and T having used the O point as the origin of the time scale (by mathematical convention O is used for the origin of the Cartesian coordinates). The interval QT was defined as the interval between the beginning of the QRS complex and the end of the T wave. The ventricular repolarization process of the heart begins in the early-activated myocardial cells while the rest of the ventricle is still depolarizing. This is why the entire duration of the ventricular repolarization is commonly associated with a measure including the QRS complex. It is also during the late 19th century that new discovery, including the electrical triggering of contraction during late refractory period, would open an entire field of quantitative electrocardiology focusing on a better understanding of the cardiac repolarization.

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Authors and Affiliations

  1. University of Rochester Medical Center, Rochester, NY, USA

    Jean-Philippe Couderc PhD, MBA (Assistant Professor of Medicine (Cardiology), Assistant Director of Heart Research Follow-up Program) & Wojciech Zareba MD, PhD (Associate Professor of Medicine (Cardiology), Director of Clinical Research, Cardiology Unit, Associate Director of Heart Research Follow-up Program)

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  1. Jean-Philippe Couderc PhD, MBA
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  2. Wojciech Zareba MD, PhD
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Editors and Affiliations

  1. eResearchTechnology Inc., Philadelphia, PA, USA

    Joel Morganroth MD (Chief Scientist, Clinical Professor of Medicine) (Chief Scientist, Clinical Professor of Medicine)

  2. University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Joel Morganroth MD (Chief Scientist, Clinical Professor of Medicine) (Chief Scientist, Clinical Professor of Medicine)

  3. Global Medical Affairs, eResearchTechnology Inc., Bridgewater, NJ

    Ihor Gussak MD, PhD, FACC (Vice President, Clinical Associate Professor of Medicine, Associate Editor) (Vice President, Clinical Associate Professor of Medicine, Associate Editor)

  4. UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ

    Ihor Gussak MD, PhD, FACC (Vice President, Clinical Associate Professor of Medicine, Associate Editor) (Vice President, Clinical Associate Professor of Medicine, Associate Editor)

  5. Journal of Electrocardiology, Bridgewater, NJ, USA

    Ihor Gussak MD, PhD, FACC (Vice President, Clinical Associate Professor of Medicine, Associate Editor) (Vice President, Clinical Associate Professor of Medicine, Associate Editor)

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Couderc, JP., Zareba, W. (2005). Assessment of Ventricular Repolarization From Body-Surface ECGs in Humans. In: Morganroth, J., Gussak, I. (eds) Cardiac Safety of Noncardiac Drugs. Humana Press. https://doi.org/10.1007/978-1-59259-884-7_6

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