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Vascular Aging

From Molecular to Clinical Cardiology

  • Chapter
Principles of Molecular Cardiology

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Advancing age is the most powerful predictor of cardiovascular morbidity, mortality, and disability. Age has traditionally been ignored as a risk factor for cardiovascular disease because it is considered a non-modifiable risk. However, close examination of the age-associated changes in cardiovascular structure and function may help explain why aging is such a strong predictor of adverse events. Findings from recent clinical studies have shown that the age-associated changes in vascular structure and function, previously not defined as clinical or subclinical diseases, are themselves risk factors for cardiovascular diseases. These novel risk factors, including intimal medial thickness, vascular stiffness, and endothelial dysfunction, alter the substrate upon which the cardiovascular diseases are superimposed; therefore, they affect the development, manifestation, severity, and prognosis of these diseases. The risk factors directly and indirectly modulate disease states, but, in turn, these diseases affect the risk factors. Thus, age-associated changes in vascular structure and function cannot be ignored and cannot be viewed as simply part of normative aging.

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Najjar, S.S., Lakatta, E.G. (2005). Vascular Aging. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Cardiology. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-878-6_29

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  • DOI: https://doi.org/10.1007/978-1-59259-878-6_29

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-201-8

  • Online ISBN: 978-1-59259-878-6

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