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Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease

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Principles of Molecular Cardiology

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Congenital heart disease (CHD), the leading noninfec-tious cause of death in infants, occurs in nearly 1% of live births and causes 10% of spontaneous abortions (1). Diagnosis and treatment of CHD have improved, and surgical palliation for many defects has resulted in an increasing population of adults surviving with complex CHD. Some forms of adult-onset heart disease originate in cardiac developmental defects. The most notable of these defects, aortic valve stenosis, is usually associated with a congenital bicuspid aortic valve and is seen in 1% of the population.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, TX

    Vidu Garg MD

  2. Departments of Pediatrics and Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX

    Deepak Srivastava MD

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  1. Vidu Garg MD
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  2. Deepak Srivastava MD
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Editors and Affiliations

  1. Department of Medicine, UNC School of Medicine, Chapell Hill, NC

    Marschall S. Runge MD, PhD

  2. Carolina Cardiovascular Biology Center, Chapel Hill, NC

    Cam Patterson MD

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© 2005 Humana Press Inc., Totowa, NJ

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Garg, V., Srivastava, D. (2005). Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease. In: Runge, M.S., Patterson, C. (eds) Principles of Molecular Cardiology. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59259-878-6_10

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  • DOI: https://doi.org/10.1007/978-1-59259-878-6_10

  • Publisher Name: Humana Press

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