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Metabotropic Glutamate Receptors

  • Chapter
Dopamine and Glutamate in Psychiatric Disorders

Abstract

l-Glutamate, one of the main neurotransmitters in the central nervous system (CNS), acts on two groups of receptors: (a) a group of ionotropic receptors that includes N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), and kainate receptors, and (2) a group of metabotropic receptors (mGluRs). Ionotropic glutamate receptors, which are ligand-gated ion channels permeable for Ca2+, Na+, and K+, are responsible for fast and relatively large changes in membrane conductance (1,2) and are covered in Chapter 4._In contrast, stimulation of mGluRs evokes a complex cascade of intracellular events that indirectly modulates neuronal excitability and produces delayed and slow synaptic currents (1,2). Both groups of glutamate receptors are involved in several physiological and pathological functions including neuronal growth and plasticity, neurotoxicity, cognitive and motor behavior, depression, anxiety, drug abuse, epilepsy, and others. Some ligands of ionotropic receptors have already been introduced to clinical practice (e.g., amantadine, memantine, d-cycloserine), whereas mGluRs may be considered as an emerging target for the treatment of several diseases (e.g., Parkinson’s disease, depression, epilepsy and others; see also Chapters 10, 19, 21, and 22).

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Authors and Affiliations

  1. Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

    Krystyna Ossowska MD, PhD

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  1. Krystyna Ossowska MD, PhD
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Editors and Affiliations

  1. Department of Neuropharmacology Zoological Institute, University of Tübingen, Tübingen, Germany

    Werner J. Schmidt PhD

  2. Department of Psychiatry, New York University School of Medicine, New York, NY

    Maarten E. A. Reith PhD

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© 2005 Humana Press Inc., Totowa, NJ

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Ossowska, K. (2005). Metabotropic Glutamate Receptors. In: Schmidt, W.J., Reith, M.E.A. (eds) Dopamine and Glutamate in Psychiatric Disorders. Humana Press. https://doi.org/10.1007/978-1-59259-852-6_5

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  • DOI: https://doi.org/10.1007/978-1-59259-852-6_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-325-1

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