Abstract
Tumor formation is a multistep process that involves uncoupling of the interdependent mechanisms of cell proliferation and differentiation. Mutations of either protooncogenes or tumor suppressor genes may confer a growth advantage to mutant cells, enabling them to proliferate more rapidly than normal cells, and to alter their interaction with their surroundings, resulting in local invasion and or distant metastases. Studies of cellular protooncogenes and tumor suppressor genes during the past decade have yielded major advances in the understanding of the molecular basis of tumorigenesis. This chapter focuses on the role of these genes in development of tumors of the endocrine system.
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Agarwal SK, Guru SC, Heppner C, et al. Menin interacts with the AP1 transcription factor JunD and represses JunD activated transcription. Cell 1999;96:143–152.
Bos J L. Ras genes in human cancer: a review. Cancer Res 1989;49:4682.
Chandrasekharappak SC, Guru SC, Manickam P, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 1997;276:404–406.
Evan GI, Littlewood TD. The role of myc in cell growth. Curr Opin Genet Dev 1993;3:44.
Ezzat S, Zheng L, Zhu XF, Wu GE, Asa SL. Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. J Clin Invest 2002;109:69–78.
Fagin JA. Minireveiw: branded from the start-distinct oncogenic initiating events may determine tumor fate in the thyroid. Mol Endocrinol 2002:16:903–911.
Hahn WC, Weinberg RA. Rules for making human tumor cells. N Engl Med 2002;347:1593–1603.
Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 1999;5:1317–1321.
Hoff AO, Cote GJ, Gagel RF. Genetic screening of endocrine disease. In: Baxter JD, Melmed S, New MI, eds. Genetics in Endocrinology. Philadelphia, PA: Lippincott Williams & Wilkins 2002:189–221.
Knudson AD. All in the (cancer) family. Nature Genet 1993;5:103.
Kroll TG, Saraff P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]. Science 2000;289:1357–1360.
Motokura T, Arnold A. Cyclins and oncogenesis. Biochem Biophys Acta 1993;1155:63.
Santoro M, et al. Activation of RET as a dominant transforming gene by germline mutations in MEN2A and MEN2B. Science 1995;267:381.
Weinberg RA. Molecular mechanisms of carcinogenesis. In: Philip Leder, David A. Clayton, Edward Rubenstein, eds. Scientific American Introdtuction to Molecular Medicine, New York, NY: Scientific American, 1994.
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© 2005 Humana Press Inc., Totowa, NJ
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Heaney, A.P., Melmed, S. (2005). Oncogenes and Tumor Suppressor Genes in Tumorigenesis of the Endocrine System. In: Melmed, S., Conn, P.M. (eds) Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59259-829-8_19
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DOI: https://doi.org/10.1007/978-1-59259-829-8_19
Publisher Name: Humana Press
Print ISBN: 978-1-58829-427-2
Online ISBN: 978-1-59259-829-8
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