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Effects of the Ketogenic Diet on Acute Seizure Models

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Book cover Epilepsy and the Ketogenic Diet

Part of the book series: Nutrition and Health ((NH))

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Abstract

The ketogenic diet (KD) is both a therapy and a tool for investigating the mechanisms of seizures and, perhaps, epilepsy. Despite our ignorance of the mechanisms by which the KD acts to alter seizures, the observation that seizure threshold can vary widely depending on what an animal eats suggests that seizure threshold is a (patho)physiological variable. The general hypothesis underlying experimental studies of the KD is that, by understanding the physiological changes consequent to a switch from a carbohydrate-based metabolism to one based on fats, we might gain insight into fundamental processes that affect ictogenesis. If a person whose seizures are controlled by a KD abandons the diet abruptly and suffers a seizure, then we might consider elevated blood glucose (or decreased ketonemia) to be ictogenic. Because central nervous system (CNS) metabolism is normally based entirely on glucose, the success of KDs in treating seizures and epilepsies presents interesting questions and opportunities.

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Authors
  1. Douglas A. Eagles
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  2. Kristopher J. Bough
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Editors and Affiliations

  1. Department of Neurology, University of Wisconsin, Madison, WI, USA

    Carl E. Stafstrom MD, PhD

  2. The Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA

    Jong M. Rho MD

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© 2004 Springer Science+Business Media New York

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Eagles, D.A., Bough, K.J. (2004). Effects of the Ketogenic Diet on Acute Seizure Models. In: Stafstrom, C.E., Rho, J.M. (eds) Epilepsy and the Ketogenic Diet. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-808-3_18

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  • DOI: https://doi.org/10.1007/978-1-59259-808-3_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-477-7

  • Online ISBN: 978-1-59259-808-3

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