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Signal Transduction and the Gasotransmitters pp 33–55Cite as

Interactions Between Gasotransmitters

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Summary

It is well established that nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) have signaling roles in the body. There are important similarities among them in their actions and generation, but there are also intriguing differences. The mechanism of action of H2S still has not been fully elucidated. It is becoming increasingly clear that there are important interactions among the gasotransmitters. There is clear evidence of links between the NO- and CO-generating systems. So far, this is most apparent in the control of the cardiovascular system, and knowledge of the function of NO has led to new therapeutic interventions. There is also a suggestion of synergy between NO and H2S that is not yet fully understood. Interactions between CO and H2S have not yet been explored, and more research is required in this area. Interactions in the immune system also require more research, and increased understanding of this area could lead to novel therapies.

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  1. Ray J. Carson
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  2. Gunter Seyffarth
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  3. Rubina Mian
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  4. Helen Maddock
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Editors and Affiliations

  1. Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada

    Rui Wang MD, PhD, FAHA

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Carson, R.J., Seyffarth, G., Mian, R., Maddock, H. (2004). Interactions Between Gasotransmitters. In: Wang, R. (eds) Signal Transduction and the Gasotransmitters. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-806-9_2

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  • DOI: https://doi.org/10.1007/978-1-59259-806-9_2

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