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Trace Elements/Minerals and Immunity

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Handbook of Nutrition and Immunity

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References

  1. Food and Nutrition Board, Institute of Medicine. (1997) Dietary Reference Intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. National Academy, Washington, DC.

    Google Scholar 

  2. Food and Nutrition Board, Institute of Medicine. (2001) Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. National Academy, Washington, DC.

    Google Scholar 

  3. World Health Organization. (1996) Trace elements in human nutrition and health. WHO, Geneva, p. 343.

    Google Scholar 

  4. Shrivastava, R., Upreti, R.K., Seth, P.K., and Chaturvedi, U.C. (2002) Effects of chromium on the immune system. FEMS Immunol. Med. Microbiol. 34, 1–7.

    CAS  Google Scholar 

  5. Sosroseno, W. (2003) Effect of sodium fluoride on the murine splenic immune response to Porphyromonas gingivalis in vitro. Immunopharmacol. Immunotoxicol. 25, 123–127.

    CAS  Google Scholar 

  6. Keen, C.L., Clegg, M.S., Hanna, L.A., et al. (2003) The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J. Nutr. 133, 1597S-1605S.

    CAS  Google Scholar 

  7. Keen, C.L. (1996) Teratogenic effects of essential trace metals: Deficiencies and excesses, in Toxicology of metals. (Chang LW, Magos L, Suzuki T, eds.) CRC, New York, pp. 977–1001.

    Google Scholar 

  8. Danzeisen, R., Fosset, C., Chariana, Z., Page, K., David, S., and McArdle, H.J. (2002) Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism. Am. J. Physiol. Cell. Physiol. 282, C472-C478.

    CAS  Google Scholar 

  9. Arthur, J.R., McKenzie, R.C., and Beckett, G.J. (2003) Selenium in the immune system. J. Nutr. 133, 1457S-1459S.

    CAS  Google Scholar 

  10. Soliman, H.M., Mercan, D., Lobo, S.S., Melot, C., and Vincent, J.L. (2003) Development of ionized hypomagnesemia is associated with higher mortality rates. Crit. Care Med. 31, 1082–1087.

    CAS  Google Scholar 

  11. Ruz, M. and Solomons, N.W. (1990) Mineral excretion during acute, dehydrating diarrhea treated with oral rehydration therapy. Pediatr. Res. 27, 170–175.

    CAS  Google Scholar 

  12. Walter, R.M., Uriu-Hare, J.Y., Olin, K.L., et al. (1991) Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care 14, 1050–1056.

    Google Scholar 

  13. Kupka, R. and Fawzi, W. (2002) Zinc nutrition and HIV infection. Nutr. Rev. 60, 69–79.

    Google Scholar 

  14. Percival, S.S. (1998) Copper and immunity. Am. J. Clin. Nutr. 67, 1064S-1068S.

    CAS  Google Scholar 

  15. Kelley, D.S., Daudu, P.A., Taylor, P.C., Mackey, B.E., and Turnlund, J.R. (1995) Effects of low-copper diets on human immune response. Am. J. Clin. Nutr. 62, 412–416.

    CAS  Google Scholar 

  16. Prohaska, J.R. and Lukasewycz, O.A. (1989) Copper deficiency during perinatal development: effects on the immune response of mice. J. Nutr. 119, 922–931.

    CAS  Google Scholar 

  17. Hopkins, R.G. and Failla, M.L. (1995) Chronic intake of a marginally low copper diet impairs in vitro activities of lymphocytes and neutrophils from male rats despite minimal impact on conventional indicators of copper status. J. Nutr. 125, 2658–2668.

    CAS  Google Scholar 

  18. Hopkins, R.G. and Failla, M.L. (1999) Transcriptional regulation of interleukin2 gene expression is impaired by copper deficiency in Jurkat human T lymphocytes. J. Nutr. 129, 596–601.

    CAS  Google Scholar 

  19. Cerone, S.I., Sansinanea, A.S., Streitenberger, S.A., Garcia, M.C., and Auza, N.J. (1998) The effect of copper deficiency on the peripheral blood cells of cattle. Vet. Res. Commun. 22, 47–57.

    CAS  Google Scholar 

  20. Spears, J.W. (2000) Micronutrients and immune function in cattle. Proc. Nutr. Soc. 59, 587–594.

    CAS  Google Scholar 

  21. Nakagawa, S., Fukata, Y., Nagata, H., Miyake, M., and Hama, T. (1993) The decreased immune responses in macular mouse, a model of Menkes’ kinky hair disease. Res. Commun. Chem. Pathol. Pharmacol. 79, 61–73.

    CAS  Google Scholar 

  22. Failla, M.L., Babu, U., and Seidel, K.E. (1988) Use of immunoresponsiveness to demonstrate that the dietary requirement for copper in young rats is greater with dietary fructose than dietary starch. J. Nutr. 118, 487–496.

    CAS  Google Scholar 

  23. Pocino, M., Baute, L., and Malave, I. (1991) Influence of the oral administration of excess copper on the immune response. Fundam. Appl. Toxicol. 16, 249–256.

    CAS  Google Scholar 

  24. Massie, H.R., Ofosu-Appiah, W., and Aiello, V.R. (1993) Elevated serum copper is associated with reduced immune response in aging mice. Gerontology 39, 136–145.

    CAS  Google Scholar 

  25. Weetman, A.P., McGregor, A.M., Campbell, H., Lazarus, J.H., Ibbertson, H.K., and Hall, R. (1983) Iodide enhances IgG synthesis by human peripheral blood lymphocytes in vitro. Acta. Endocrinol. (Copenh.) 103, 210–215.

    CAS  Google Scholar 

  26. Venturi, S., Donati, F.M., Venturi, A., Venturi, M., Grossi, L., and Guidi, A. (2000) Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach. Adv. Clin. Path. 4, 11–17.

    CAS  Google Scholar 

  27. Marani, L. and Venturi, S. (1986) [Iodine and delayed immunity]. Minerva. Med. 77, 805–809.

    CAS  Google Scholar 

  28. DeLong, G.R., Leslie, P.W., Wang, S.H., et al. (1997) Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet 350, 771–773.

    CAS  Google Scholar 

  29. Wenzel, B.E., Chow, A., Baur, R., Schleusener, H., and Wall, J.R. (1998) Natural killer cell activity in patients with Graves’ disease and Hashimoto’s thyroiditis. Thyroid 8, 1019–1022.

    CAS  Google Scholar 

  30. Dai, Y.D., Rao, V.P., and Carayanniotis, G. (2002) Enhanced iodination of thyroglobulin facilitates processing and presentation of a cryptic pathogenic peptide. J. Immunol. 168, 5907–5911.

    CAS  Google Scholar 

  31. Pedersen, I.B., Knudsen, N., Jorgensen, T., Perrild, H., Ovesen, L., and Laurberg, P. (2003) Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin. Endocrinol. (Oxf.) 58, 36–42.

    Google Scholar 

  32. Loviselli, A., Velluzzi, F., Mossa, P., et al. (2001) The Sardinian Autoimmunity Study: 3. Studies on circulating antithyroid antibodies in Sardinian schoolchildren: relationship to goiter prevalence and thyroid function. Thyroid 11, 849–857.

    CAS  Google Scholar 

  33. Stoltzfus, R.J. Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs. J. Nutr. 131, 697S-700S; discussion 700S–701S.

    Google Scholar 

  34. Failla, M.L. (2003) Trace elements and host defense: recent advances and continuing challenges. J. Nutr. 133, 1443S-1447S.

    CAS  Google Scholar 

  35. Gera, T. and Sachdev, H.P. (2002) Effect of iron supplementation on incidence of infectious illness in children: systematic review. Br. Med. J. 325, 1142.

    CAS  Google Scholar 

  36. de Silva, A., Atukorala, S., Weerasinghe, I., and Ahluwalia, N. (2003) Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: a randomized controlled study in Colombo, Sri Lanka. Am. J. Clin. Nutr. 77, 234–241.

    Google Scholar 

  37. Nussenblatt, V. and Semba, R.D. (2002) Micronutrient malnutrition and the pathogenesis of malarial anemia. Acta. Trop. 82, 321–337.

    CAS  Google Scholar 

  38. Afacan, Y.E., Hasan, M.S., and Omene, J.A. (2002) Iron deficiency anemia in HIV infection: immunologic and virologic response. J. Natl. Med. Assoc. 94, 73–77.

    Google Scholar 

  39. Gordeuk, V.R., Delanghe, J.R., Langlois, M.R., and Boelaert, J.R. (2001) Iron status and the outcome of HIV infection: an overview. J. Clin. Virol. 20, 111–115.

    CAS  Google Scholar 

  40. Totin, D., Ndugwa, C., Mmiro, F., Perry, R.T., Jackson, J.B., Semba, R.D. (2002) Iron deficiency anemia is highly prevalent among human immunodeficiency virus-infected and uninfected infants in Uganda. J. Nutr. 132, 423–429.

    CAS  Google Scholar 

  41. Verhoef, H., West, C.E., Ndeto, P., Burema, J., Beguin, Y., Kok, F.J. (2001) Serum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria. Am. J. Clin. Nutr. 74, 767–775.

    CAS  Google Scholar 

  42. Hambidge M. (2003) Biomarkers of trace mineral intake and status. J. Nutr. 133 Suppl 3, 948S-955S.

    CAS  Google Scholar 

  43. Malpuech-Brugere, C., Nowacki, W., Gueux, E., et al. (1999) Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress. Br. J. Nutr. 81, 405–411.

    CAS  Google Scholar 

  44. Ashkenazy, Y., Moshonov, S., Fischer, G., et al. (1990) Magnesium-deficient diet aggravates anaphylactic shock and promotes cardiac myolysis in guinea pigs. Magnes. Trace Elem. 9, 283–288.

    CAS  Google Scholar 

  45. Malpuech-Brugere, C., Rock, E., Astier, C., Nowacki, W., Mazur, A., and Rayssiguier, Y. (1998) Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis. Life Sci. 63, 1815–1822.

    CAS  Google Scholar 

  46. Malpuech-Brugere, C., Nowacki, W., Daveau, M., et al. (2000) Inflammatory response following acute magnesium deficiency in the rat. Biochim. Biophys. Acta. 1501, 91–98.

    CAS  Google Scholar 

  47. Bussiere, F.I., Mazur, A., Fauquert, J.L., Labbe, A., Rayssiguier, Y., and Tridon, A. (2002) High magnesium concentration in vitro decreases human leukocyte activation. Magnes. Res. 15, 43–48.

    CAS  Google Scholar 

  48. Salem, M., Kasinski, N., Munoz, R., and Chernow, B. (1995) Progressive magnesium deficiency increases mortality from endotoxin challenge: protective effects of acute magnesium replacement therapy. Crit. Care Med. 23, 108–118.

    CAS  Google Scholar 

  49. Weglicki, W.B., Dickens, B.F., Wagner, T.L., Chmielinska, J.J., and Phillips, T.M. (1996) Immunoregulation by neuropeptides in magnesium deficiency: exvivo effect of enhanced substance P production on circulating T lymphocytes from magnesium-deficient mice. Magnes. Res. 9, 3–11.

    CAS  Google Scholar 

  50. Bussiere, F.I., Gueux, E., Rock, E., et al. (2002) Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration. Br. J. Nutr. 87, 107–113.

    CAS  Google Scholar 

  51. Kramer, J.H., Mak, I.T., Phillips, T.M., and Weglicki, W.B. (2003) Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress. Exp. Biol. Med. (Maywood) 228, 665–673.

    CAS  Google Scholar 

  52. Petrault, I., Zimowska, W., Mathieu, J., et al. (2002) Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency. Biochim. Biophys. Acta. 1586, 92–98.

    CAS  Google Scholar 

  53. Bussiere, FI., Gueux, E., Rock, E., Mazur, A., and Rayssiguier, Y. (2002) Protective effect of calcium deficiency on the inflammatory response in magnesiumdeficient rats. Eur. J. Nutr. 41, 197–202.

    CAS  Google Scholar 

  54. Vormann, J., Michalski, L., and Gunther, T. (1996) Cellular and humoral immunity in rats after gestational zinc or magnesium deficiency. J. Nutr. Biochem. 7, 327–332.

    CAS  Google Scholar 

  55. Turner, R.E., Langkamp-Henken, B., Littell, R.C., Lukowski, M.J., and Suarez, M.F. (2003) Comparing nutrient intake from food to the estimated average requirements shows middle- to upper-income pregnant women lack iron and possibly magnesium. J. Am. Diet. Assoc. 103, 461–466.

    Google Scholar 

  56. Suitor, C.W. and Gleason, P.M. (2002) Using Dietary Reference Intake-based methods to estimate the prevalence of inadequate nutrient intake among schoolaged children. J. Am. Diet. Assoc. 102, 530–536.

    Google Scholar 

  57. Britton, J., Pavord, I., Richards, K., et al. (1994) Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample. Lancet 344, 357–362.

    CAS  Google Scholar 

  58. Bessmertny, O., DiGregorio, R.V., Cohen, H., et al. (2002) A randomized clinical trial of nebulized magnesium sulfate in addition to albuterol in the treatment of acute mild-to-moderate asthma exacerbations in adults. Ann. Emerg. Med. 39, 585–591.

    Google Scholar 

  59. Porter, R.S., Nester, Braitman, L.E., Geary, U., and Dalsey, W.C. (2001) Intravenous magnesium is ineffective in adult asthma, a randomized trial. Eur. J. Emerg. Med. 8, 9–15.

    CAS  Google Scholar 

  60. Doelman, C.J. and Bast, A. (1990) Oxygen radicals in lung pathology. Free Radic. Biol. Med. 9, 381–400.

    CAS  Google Scholar 

  61. Keen, C.L., Ensunsa, J.L., and Clegg, M.S. (2000) Manganese metabolism in animals and humans including the toxicity of manganese. Met. Ions. Biol. Syst. 37, 89–121.

    CAS  Google Scholar 

  62. Friedman, B.J., Freeland-Graves, J.H., Bales, C.W., et al. (1987) Manganese balance and clinical observations in young men fed a manganese-deficient diet. J. Nutr. 117, 133–143.

    CAS  Google Scholar 

  63. Davis, C.D. and Greger, J.L. (1992) Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. Am. J. Clin. Nutr. 55, 747–752.

    CAS  Google Scholar 

  64. Davis, C.D., Malecki, E.A., and Greger, J.L. (1992) Interactions among dietary manganese, heme iron, and nonheme iron in women. Am. J. Clin. Nutt. 56, 926–932.

    CAS  Google Scholar 

  65. Spillmann, C., Osorio, D., and Waugh, R. (2002) Integrin activation by divalent ions affects neutrophil homotypic adhesion. Ann. Biomed. Eng. 30, 1002–1011.

    CAS  Google Scholar 

  66. Edwards, A.S. and Newton, A.C. (1997) Regulation of protein kinase C betall by its C2 domain. Biochemistry 36, 15615–15623.

    CAS  Google Scholar 

  67. Xu, X. and Hakansson, L. (2002) Degranulation of primary and secondary granules in adherent human neutrophils. Scand. J. Immunol. 55, 178–188.

    CAS  Google Scholar 

  68. Kalb, A.J., Habash, J., Hunter, N.S., Price, H.J., Raftery, J., and Helliwell, J.R. (2000) Manganese(II) in concanavalin A and other lectin proteins. Met. Ions. Biol. Syst. 37, 279–304.

    CAS  Google Scholar 

  69. Keen, C., Lonnerdal, B., and Hurley, L.S. (1984) Manganese, in Biochemistry of the essential ultratrace elements. (Frieden E, ed.) Plenum, New York, pp. 89–132.

    Google Scholar 

  70. Epperly, M.W., Guo, H.L., Jefferson, M., et al. (2003) Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy. Gene Ther. 10, 163–171.

    CAS  Google Scholar 

  71. Bertera, S., Crawford, M.L., Alexander, A.M., et al. (2003) Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes 52, 387–393.

    CAS  Google Scholar 

  72. Zhang, Y.C., Pileggi, A., Agarwal, A., et al. (2003) Adeno-associated virusmediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes 52, 708–716.

    CAS  Google Scholar 

  73. Srisuchart, B., Taylor, M.J., and Sharma, RP. (1987) Alteration of humoral and cellular immunity in manganese chloride-treated mice. J. Toxicol. Environ. Health 22, 91–99.

    CAS  Google Scholar 

  74. Takagi, Y., Okada, A., Sando, K., Wasa, M., Yoshida, H., and Hirabuki, N. (2002) Evaluation of indexes of in vivo manganese status and the optimal intravenous dose for adult patients undergoing home parenteral nutrition. Am. J. Clin. Nutr. 75, 112–118.

    CAS  Google Scholar 

  75. Kryukov, G.V. and Gladyshev, V.N. (2002) Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods. Methods Enzymol. 347, 84–100.

    CAS  Google Scholar 

  76. Lescure, A., Gautheret, D., and Krol, A. (2002) Novel selenoproteins identified from genomic sequence data. Methods Enzymol. 347, 57–70.

    CAS  Google Scholar 

  77. Arthur, J.R. (2000) The glutathione peroxidases. Cell. Mol. Liife Sci. 57, 1825–1835.

    CAS  Google Scholar 

  78. Imai, H. and Nakagawa, Y. (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free. Radical. Biol. Med. 34, 145–169.

    CAS  Google Scholar 

  79. Brigelius-Flohe, R., Banning, A., and Schnurr, K. (2003) Selenium-dependent enzymes in endothelial cell function. Antioxidants Redox Signaling 5, 205–215.

    CAS  Google Scholar 

  80. Beck, M.A., Levander, O.A., and Handy, J. (2003) Selenium deficiency and viral infection. J. Nutr. 133, 1463S-1467S.

    CAS  Google Scholar 

  81. Prabhu, K.S., Zamamiri-Davis, F., Stewart, J.B., Thompson, J.T., Sordillo, L.M., and Reddy, C.C. (2002) Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factorkappa B in up-regulation. Biochem. J. 366, 203–209.

    CAS  Google Scholar 

  82. Gartner, R., Gasnier, B.C., Dietrich, J.W., Krebs, B., Angstwurm, M.W. (2002) Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. J. Clin. Endocrinol. Metab. 87, 1687–1691.

    CAS  Google Scholar 

  83. Baum, M.K., Miguez-Burbano, M.J., Campa, A., and Shor-Posner, G. (2000) Selenium and interleukins in persons infected with human immunodeficiency virus type 1. J. Infect. Dis. 182 Suppl 1, S69-S73.

    CAS  Google Scholar 

  84. Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J.P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am. J. Clin. Nutr. 53, 1323–1328.

    Google Scholar 

  85. Bonomini, M., Forster, S., De Risio, F., et al. (1995) Effects of selenium supplementation on immune parameters in chronic uraemic patients on haemodialysis. Nephrol. Dial. Transplant. 10, 1654–1661.

    CAS  Google Scholar 

  86. Popova, N.V. (2002) Perinatal selenium exposure decreases spontaneous liver tumorogenesis in CBA mice. Cancer. Lett. 179, 39–42.

    CAS  Google Scholar 

  87. Jackson, M.J., Broome, C.S., and McArdle, F. (2003) Marginal dietary selenium intakes in the UK: are there functional consequences? J. Nutr. 133, 1557S-1559S.

    CAS  Google Scholar 

  88. Duffield-Lillico, A.J., Dalkin, B.L., Reid, ME., et al. (2003) Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. Br. J. Urol. Int. 91, 608–612.

    CAS  Google Scholar 

  89. Reid, M.E., Duffield-Lillico, A.J., Garland, L., Turnbull, B.W., Clark, L.C., and Marshall, J.R. (2002) Selenium supplementation and lung cancer incidence: an update of the nutritional prevention of cancer trial. Cancer. Epidemiol. Biomarkers. Prey. 11, 1285–1291.

    CAS  Google Scholar 

  90. Maehira, F., Luyo, G.A., Miyagi, I., et al. (2002) Alterations of serum selenium concentrations in the acute phase of pathological conditions. Clin. Chim. Acta. 316, 137–146.

    CAS  Google Scholar 

  91. Food and Nutrition Board, Institute of Medicine. (2000) Selenium. Dietary Reference Intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academy, Washington, DC, pp. 284–324.

    Google Scholar 

  92. Zago, M.P. and Oteiza, P.I. (2001) The antioxidant properties of zinc: interactions with iron and antioxidants. Free. Radic. Biol. Med. 31, 266–274.

    CAS  Google Scholar 

  93. Maret, W. (2003) Cellular zinc and redox states converge in the metallothionein/ thionein pair. J. Nutr. 133, 1460S-1462S.

    CAS  Google Scholar 

  94. Cousins, R.J., Blanchard, R.K., Moore, J.B., et al. (2003) Regulation of zinc metabolism and genomic outcomes. J. Nutr. 133, 1521S-1526S.

    CAS  Google Scholar 

  95. Keen, C.L. and Gershwin, M.E. (1990) Zinc deficiency and immune function. Annu. Rev. Nutr. 10, 415–431.

    CAS  Google Scholar 

  96. Fraker, P.J., King, L.E., Laakko, T., and Vollmer, T.L. (2000) The dynamic link between the integrity of the immune system and zinc status. J. Nutr. 130, 1399S-1406S.

    CAS  Google Scholar 

  97. Cui, L., Blanchard, R.K., and Cousins, R.J. (2003) The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1 alpha is rapidly reversed by zinc repletion. J. Nutr. 133, 51–56.

    CAS  Google Scholar 

  98. Dardenne, M. Zinc and immune function. (2002) Eur. J. Clin. Nutr. 56 Suppl 3, S20–S23.

    CAS  Google Scholar 

  99. King, L.E., Osati-Ashtiani, F., and Fraker, P.J. (2002) Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. J. Nutr. 132, 974–979.

    CAS  Google Scholar 

  100. Prasad, A.S. (2000) Effects of zinc deficiency on Thl and Th2 cytokine shifts. J. Infect. Dis. 182 Suppl 1, S62—S68.

    Google Scholar 

  101. Pinna, K., Kelley, D.S., Taylor, P.C., and King, J.C. (2002) Immune functions are maintained in healthy men with low zinc intake. J. Nutr. 132, 2033–2036.

    CAS  Google Scholar 

  102. Ibs, K.H. and Rink, L. (2003) Zinc-altered immune function. J. Nutr. 133, 1452S-1456S.

    CAS  Google Scholar 

  103. Osendarp, S.J., West, C.E., and Black, R.E. (2003) The need for maternal zinc supplementation in developing countries: an unresolved issue. J. Nutr. 133, 817S-827S.

    CAS  Google Scholar 

  104. Cuevas, L.E., Almeida, L.M., Mazunder, P., et al. (2002) Effect of zinc on the tuberculin response of children exposed to adults with smear-positive tuberculosis. Ann. Trop. Paediatr. 22, 313–319.

    CAS  Google Scholar 

  105. Shankar, A.H., Genton, B., Baisor, M., et al. (2000) The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea. Am. J. Trop. Med. Hyg. 62, 663–669.

    CAS  Google Scholar 

  106. Dreyfuss, M.L. and Fawzi, W.W. (2002) Micronutrients and vertical transmission of HIV-1. Am. J. Clin. Nutr. 75, 959–970.

    CAS  Google Scholar 

  107. Siberry, G., Ruff, A., and Black, R. (2002) Zinc and immunodeficiency virus infection. Nutr. Res. 22, 527–538.

    CAS  Google Scholar 

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  1. Carl L. Keen
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  2. Janet Y. Uriu-Adams
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  3. Jodi L. Ensunsa
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  4. M. Eric Gershwin
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Editor information

Editors and Affiliations

  1. Division of Rheumatology, Allergy, and Clinical Immunology, University of California School of Medicine, Davis, CA, USA

    M. Eric Gershwin MD

  2. Micronutrient Global Leadership Project, Washington, DC, USA

    Penelope Nestel PhD

  3. Department of Nutrition, University of California, Davis, CA, USA

    Carl L. Keen PhD

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Keen, C.L., Uriu-Adams, J.Y., Ensunsa, J.L., Gershwin, M.E. (2004). Trace Elements/Minerals and Immunity. In: Gershwin, M.E., Nestel, P., Keen, C.L. (eds) Handbook of Nutrition and Immunity. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-790-1_6

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  • DOI: https://doi.org/10.1007/978-1-59259-790-1_6

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  • Print ISBN: 978-1-4684-9864-6

  • Online ISBN: 978-1-59259-790-1

  • eBook Packages: Springer Book Archive

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