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Cancer Gene Therapy pp 405–426Cite as

Molecular Imaging of Cancer Gene Therapy

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Part of the book series: Contemporary Cancer Research ((CCR))

Abstract

Applications of noninvasive imaging in cancer gene therapy research and clinical practice fall into three categories. First, “tagged” tumor cells can be used to monitor cell fates in vivo. Target tumor cells can be labeled for noninvasive imaging, either by transfer of ex vivo-labeled tumor cells to host animals or by the development of transgenic animal models in which target tumor cells express reporters that can be noninvasively imaged. The response of imagable target tumor cells to chemotherapy, immunotherapy, gene therapy, cell therapy, and multimodality therapies can then be noninvasively monitored (1). Although an important tool in preclinical cancer research studies in general and gene therapy research in particular, the use of noninvasive imaging to monitor the fate of tagged target tumor cells is not extensively reviewed here.

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Authors and Affiliations

  1. Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, CA

    Harvey R. Herschman

  2. Department of Pharmacology, University of California at Los Angeles, Los Angeles, CA

    Harvey R. Herschman

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  1. Harvey R. Herschman
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Editors and Affiliations

  1. Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  2. Division of Human Gene Therapy, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  3. Division of Human Gene Therapy, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  4. Division of Human Gene Therapy, Department of Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

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© 2005 Humana Press Inc., Totowa, NJ

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Herschman, H.R. (2005). Molecular Imaging of Cancer Gene Therapy. In: Curiel, D.T., Douglas, J.T. (eds) Cancer Gene Therapy. Contemporary Cancer Research. Humana Press. https://doi.org/10.1007/978-1-59259-785-7_27

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