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Dendritic Cells

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Cancer Gene Therapy

Part of the book series: Contemporary Cancer Research ((CCR))

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Abstract

Dendritic cells (DCs) are the principal immune cells priming naïve T lymphocytes to initiate adaptive immunity. DCs have been referred to as “nature’s adjuvant” owing to their potency in igniting immune responses (1). They originate from proliferating hematopoietic progenitor cells in bone marrow and enter blood as nonproliferating precursor cells. These precursor cells then seed all tissues, in which they differentiate into immature DCs that sample the environment for “danger” or foreign antigens. If such is encountered, they migrate to locally draining lymph nodes, during which transit they undergo a process of maturation. In maturation, their capacity to acquire antigen is lost simultaneous with their acquisition of an enormous capacity to prime naïve T cells.

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Authors and Affiliations

  1. Section of Hematology and Medical Oncology, Tulane Medical School, New Orleans, LA

    Weiping Zou, Shuang Wei & Tyler J. Curiel

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  1. Weiping Zou
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  2. Shuang Wei
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  3. Tyler J. Curiel
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Editors and Affiliations

  1. Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  2. Division of Human Gene Therapy, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  3. Division of Human Gene Therapy, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

  4. Division of Human Gene Therapy, Department of Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL

    David T. Curiel MD, PhD  & Joanne T. Douglas PhD  & 

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© 2005 Humana Press Inc., Totowa, NJ

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Zou, W., Wei, S., Curiel, T.J. (2005). Dendritic Cells. In: Curiel, D.T., Douglas, J.T. (eds) Cancer Gene Therapy. Contemporary Cancer Research. Humana Press. https://doi.org/10.1007/978-1-59259-785-7_11

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