Strategies for the Chemoprevention of Prostate Cancer

  • Ronald Lieberman
  • Jacob Kagan
  • Margaret G. House
  • Joseph Kelaghan
  • David J. Kansal
  • Howard L. Parnes
Part of the Current Clinical Urology book series (CCU)


Carcinogenesis is a multistep process driven by genetic and epigenetic alterations that disrupt the regulatory pathways controlling cellular proliferation, programmed cell death (apoptosis), angiogenesis, and differentiation (1–3). The age-dependent incidence of most cancers and the recognition that precursor lesions, representing intermediate stages between normal and malignant cells, may precede invasive cancer by 20 yr or more, suggests that malignant transformation generally occurs over decades (4–10) (Fig. 1). The protracted nature of this process provides an opportunity to intervene before the malignant phenotype is established. This may be done with life-style changes such as diet and exercise, or by chemoprevention, the administration of natural or synthetic agents to reverse, inhibit, slow, or prevent the development of cancer (11).


Prostate Cancer Androgen Receptor Proliferate Cell Nuclear Antigen Natl Cancer Inst Prostate Cancer Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Ronald Lieberman
  • Jacob Kagan
  • Margaret G. House
  • Joseph Kelaghan
  • David J. Kansal
  • Howard L. Parnes

There are no affiliations available

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