Conformal External Beam Radiation Therapy
- 138 Downloads
External beam radiation therapy (RT) has been an essential component in the curative treatment of prostrate cancer for several decades. During the early clinical applications of cobalt beam teletherapy, the methods used to treat prostrate cancer relied on broad anatomic and physical principles that were applied in a general fashion to all patients with presumed localized disease. The target tissues (including the prostate, seminal vesicles, and pelvic lymph nodes) were not differentiated from the surrounding organs such as the bladder and the rectum, limiting the application of high radiation doses. The higher the radiation dose administered to a given volume of cancer, the more likely it is that the cancer will be permanently controlled—this is a basic tenet in radiation biology that has been clinically validated in several reports, both retrospective and prospective (1–7). In the last decade or so, the availability of high-energy megavoltage X-ray machines and the incorporation of cross-sectional imaging modalities and computerized treatment planning systems have been instrumental in the evolution of external radiation beam therapy as a safer and more effective option for men with localized prostate cancer. This chapter highlights the relevant clinical applied anatomy, the technical aspects of conformal external beam radiation therapy techniques, and the current disease control and quality of life outcome expectations.
KeywordsProstate Cancer Seminal Vesicle Radiat Oncol Biol Phys Intensity Modulate Radiation Therapy Localize Prostate Cancer
Unable to display preview. Download preview PDF.
- 7.Shipley WU, Verhey LJ, Munzenrider JE, et al. Advanced prostate cancer: the results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional does irradiation using photons alone. Int J Radiat Oncol Biol Phys 1995; 32: 3–12.PubMedCrossRefGoogle Scholar
- 8.Mizowaki T, Cohen GN, Fung AY, et al. Towards integrating functional imaging in the treatment of prostate cancer with radiation: the registration of the MR spectroscopy imaging to ultrasoundCT images and its implementation in treatment planning. Int J Radiat Oncol Biol Phys 2002; 54: 1558–1564.PubMedCrossRefGoogle Scholar
- 29.Roach M, DeSilvio M, Lawton C, et al. Neoadjuvant hormonal therapy (NHT) with whole-pelvic (WP) radiotherapy (RT) improves progression-free survival (PFS): RTOG (Radiation Therapy Oncology Group) 9413, a phase III randomized trial. J Urol 2002;10:1904–1911, Abs. #500164.Google Scholar
- 34.American Society for Therapeutic Radiology and Oncology Consensus Panel. Consensus statement: guidelines for PSA following radiation therapy. Int J Radiat Oncol Biol Phys 1997; 37: 1035–1041.Google Scholar