Skip to main content

Evaluation and Management of Hyperlipidemia for Stroke Prevention

  • Chapter
Handbook of Stroke Prevention in Clinical Practice

Part of the book series: Current Clinical Neurology ((CCNEU))

  • 250 Accesses

Abstract

Observational studies and clinical trials have established that lipid disorders (elevated serum total cholesterol [TC], low-density lipoprotein cholesterol [LDLc], or triglycerides [TGs] and reduced serum high-density lipoprotein cholesterol [HDLc]) are independently associated with the risk of coronary heart disease (CHD). Hyperlipidemia was also clearly associated with progression of carotid and peripheral atherosclerosis and intima-media thickness (IMT), a marker of early atherosclerosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amarenco P. Hypercholesterolemia, lipid-lowering agents, and the risk for brain infarction. Neurology 2001;57(Suppl 2):S35—S44.

    Article  Google Scholar 

  2. Hachinski V, Graffagnino C, Beaudry M, et al. Lipids and stroke: a paradox resolved. Arch Neurol 1996;53:303–308.

    Article  PubMed  CAS  Google Scholar 

  3. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomized placebo-controlled trial. Lancet 2002;360:7–22.

    Article  Google Scholar 

  4. The Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Bethesda, MD: National Heart, Lung and Blood Institute, National Institutes of Health, May 2001. NIH Publication 01–3305. (Summary published in JAMA 2001;285(19):2486–2497)

    Google Scholar 

  5. Van Horn L, McDonald A, Peters E, Gernhofer N. Dietary management of cardiovascular disease: a year 2002 perspective. Nutr Clin Care 2001;4:314–331.

    Article  Google Scholar 

  6. Krauss RM, Eckel RH, Howard B, et al. AHA dietary guidelines. Revision 2000: a statement for health care professionals from the nutrition committee of the American Heart Association. Circulation 2000;102;2284–2299.

    Article  PubMed  CAS  Google Scholar 

  7. Kromhout D, Menotti A, Kesteloot H, Sana S. Prevention of coronary heart disease by diet and lifestyle. Evidence from prospective cross-cultural, cohort, and intervention studies. Circulation 2002;105:893–898.

    Article  PubMed  Google Scholar 

  8. US Department of Agriculture and US Department of Health and Human Services. Nutrition and Your Health: Dietary Guidelines for Americans. 5th ed. Washington, DC: US Department of Agriculture, 2000. Home and Garden Bulletin 232.

    Google Scholar 

  9. Bernini F, Poli A, Paoletti R. Safety of HMG-CoA reductase inhibitors: focus on atorvastatin. Cardiovasc Drugs Then 2001;15:211–218.

    Article  CAS  Google Scholar 

  10. Pasternak RC, Smith SC Jr, Bairy-Merz CN, et al. ACC/AHA/NHLBI advisory on the use and safety of statins. J Am Coll Cardiol 2002;40:568–573.

    Article  Google Scholar 

  11. Chong PH, Seeger JD, Franklin C. Clinically relevant differences between the statins: implications for therapeutic selection. Am J Med 2001;111:390–400.

    Article  PubMed  CAS  Google Scholar 

  12. Batiste MC, Schaefer EJ. Diagnosis and management of lipoprotein abnormalities. Nutr Clin Care 2002;5:115–123.

    Article  PubMed  Google Scholar 

  13. Lousberg TR, Denham AM, Rasmussen JR. A comparison of clinical outcome studies among cholesterol-lowering agents. Ann Pharmacother 2001;35:1599–1607.

    Article  PubMed  CAS  Google Scholar 

  14. Stein EA. Managing dyslipidemia in the high-risk patient. Am J Cardiol 2002; 89(Suppl):50C-57C.

    Article  PubMed  Google Scholar 

  15. Reaven G. Metabolic syndrome. Pathophysiology and implications for management of cardiovascular disease. Circulation 2002;106:286–288.

    Article  PubMed  Google Scholar 

  16. Goldstein JL, Brown MS. The cholesterol quartet. Science 2000;292:1310–1312.

    Article  Google Scholar 

  17. Rader DJ, Rosas S. Management of selected lipid abnormalities. Hypertriglyceridemia, low HDL cholesterol, lipoprotein(a), in thyroid and renal disease, and posttransplantation. Med Clin North Am 2000;84:43–61.

    Article  PubMed  CAS  Google Scholar 

  18. Jonkers IJAM, Smelt AHM, yen der Laarse A. Hypertriglyceridemia. Associated risks and effect of drug treatment. Am J Cardiovasc Drugs 2001;1:455–466.

    Article  PubMed  CAS  Google Scholar 

  19. Danesh J, Collins R, Peto R. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation 2000;102:1082–1085.

    Article  PubMed  CAS  Google Scholar 

  20. Luc G, Bard JM, Arveiler D, et al. Lipoprotein(a) as a predictor of coronary heart disease: the PRIME Study. Atherosclerosis 2002;163:377–384.

    Article  PubMed  CAS  Google Scholar 

  21. Haralampos MJ, Winder AF, Mikhailidis DP. Lipoprotein(a) and stroke. J Clin Pathol 2000;53:487–496.

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Topcuoglu, M.A., Buonanno, F.S., Kelly, P.J. (2004). Evaluation and Management of Hyperlipidemia for Stroke Prevention. In: Furie, K.L., Kelly, P.J. (eds) Handbook of Stroke Prevention in Clinical Practice. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-769-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-769-7_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9856-1

  • Online ISBN: 978-1-59259-769-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics