Abstract
Over the past two decades, our understanding of the complex molecular underpinnings of cancer has increased dramatically. While we know that the genetic events associated with cancer are quite diverse, with much genetic heterogeneity within and among tumors, careful analysis of the complex data has revealed a limited number of common categories of acquired capabilities of cancers (1). As described by Hanahan and Weinberg, these capabilities include insensitivity to antigrowth signals, independence from growth signals, ability to evade apoptosis, unlimited replicative potential, sustained angiogenesis, and the abililty to invade tissue and metastasize. Although the acquisition sequence of each of these capabilities can vary, as can the specific molecular changes that lead to the acquired capability, the notion that there are a limited number of such events, and that they are common to diverse tumors, provides a firm foundation for additional discovery, improved cancer detection, and new intervention strategies.
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© 2005 Humana Press Inc., Totowa, NJ
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Strausberg, R.L., Riggins, G.J. (2005). Enabling Discovery Through Online Cancer Genome Databases and Analytic Tools. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59259-768-0_7
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DOI: https://doi.org/10.1007/978-1-59259-768-0_7
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