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Inducible Nitric Oxide Synthase as a Target for Chemoprevention

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Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Nitric oxide (NO.) was first described as endothelium-derived relaxation factor (EDRF) in the 1980s (1–5). Since then, it has been shown to be a key signaling molecule that mediates both physiological and pathological processes, including vasodilation (6), neurotransmission (7), host defense, (8), platelet aggregation (9,10), and iron metabolism (11,12). Increasing evidence suggests that NO. is a pivotal mediator of inflammatory-associated carcinogenesis because of its impact on DNA damage, cell cycle, and modifications of cancer-related proteins (13–18).

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Authors
  1. Lorne J. Hofseth PhD
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  2. Tomohiro Sawa PhD
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  3. S. Perwez Hussain PhD
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  4. Curtis C. Harris MD
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Editors and Affiliations

  1. National Institutes of Health, Rockville, MD, USA

    Gary J. Kelloff MD  & Ernest T. Hawk MD, MPH  & 

  2. CCS Associates, Mountain View, CA, USA

    Caroline C. Sigman PhD

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Hofseth, L.J., Sawa, T., Hussain, S.P., Harris, C.C. (2004). Inducible Nitric Oxide Synthase as a Target for Chemoprevention. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_8

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