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Lipoxygenases as Targets for Cancer Prevention

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Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Although the cyclooxygenase (COX) metabolites of arachidonic acid (AA; 20:4; eicosatetraenoic acid) metabolism have received more attention than the metabolites of the lipoxygenases (LOX), there is growing evidence that inhibition of LOX offers an effective means of cancer (and other disease) prevention. As a family, LOX are dioxygenase enzymes that incorporate molecular oxygen into some polyunsaturated fatty acids, particularly AA and linoleic acid (LA; 18:2; octadecadienoic acid). LOX are widely distributed in plants, fungi, and mammals, but are absent in most bacteria and yeasts (1–3). The recognition that AA can be metabolized to COX and LOX products that are ligands for specific receptors has suggested their potential importance in regulating cell growth and/or differentiation. However, there is uncertainty regarding which metabolites are the most important or how they contribute to transformation, tumor growth, and metastases. It is the goal of this chapter to provide information on the known tissue distribution of the various LOX family members, their products, and the effect of inhibiting LOX in specific organ models of cancer.

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Authors
  1. Susan M. Fischer PhD
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  2. Russell D. Klein PhD
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Editors and Affiliations

  1. National Institutes of Health, Rockville, MD, USA

    Gary J. Kelloff MD  & Ernest T. Hawk MD, MPH  & 

  2. CCS Associates, Mountain View, CA, USA

    Caroline C. Sigman PhD

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Fischer, S.M., Klein, R.D. (2004). Lipoxygenases as Targets for Cancer Prevention. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_7

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  • DOI: https://doi.org/10.1007/978-1-59259-767-3_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-342-8

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