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Chemoprevention by Isothiocyanates

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Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Isothiocyanates are among the most effective known chemopreventive agents (1). Examples of complete inhibition of carcinogenicity in laboratory animals through relatively low doses of isothiocyanates are not unusual. Many isothiocyanates occur naturally as glucosinolate conjugates in frequently consumed cruciferous vegetables (2). Consistent with the animal carcinogenicity data, three recent epidemiologic studies have demonstrated that human consumption of isothiocyanates in vegetables decreases lung cancer risk (3–5). Other studies have shown that consumption of genus Brassica vegetables is protective against lung cancer (6). Collectively, these data indicate that isothiocyanates have substantial potential for chemoprevention of human cancers.

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  1. Stephen S. Hecht PhD
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  1. National Institutes of Health, Rockville, MD, USA

    Gary J. Kelloff MD  & Ernest T. Hawk MD, MPH  & 

  2. CCS Associates, Mountain View, CA, USA

    Caroline C. Sigman PhD

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Hecht, S.S. (2004). Chemoprevention by Isothiocyanates. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_2

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  • DOI: https://doi.org/10.1007/978-1-59259-767-3_2

  • Publisher Name: Humana Press, Totowa, NJ

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