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Prostacyclin and Lung Cancer Chemoprevention

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Cancer Chemoprevention

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Eicosanoids are a family of bioactive lipid metabolites of arachidonic acid (AA). AA is hydrolyzed from membrane phospholipids through the action of phospholipase A2 (PLA2). Free AA can then be metabolized through three major pathways: cyclooxygenase (COX) to produce prostaglandins (PG) and thromboxane, lipoxygenase (LOX) to produce leukotrienes and hydroxy eicosatetraenoic acid (HETES), and cytochrome P-450 to produce epoxyeicosatrienoic acids (EETs). Most studies that have examined eicosanoids and cancer have focused on COX-2 in colon cancer. Elevated COX-2 expression was first demonstrated in colon cancer, in which colon tumors increased COX-2 expression compared to normal colon tissues (1).

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Authors
  1. Robert L. Keith MD
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  2. York E. Miller MD
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  3. Paul A. Bunn Jr. MD
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  4. Patrick Nana-Sinkam MD
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  5. Raphael A. Nemenoff PhD
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  6. Mark W. Geraci MD
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Editors and Affiliations

  1. National Institutes of Health, Rockville, MD, USA

    Gary J. Kelloff MD  & Ernest T. Hawk MD, MPH  & 

  2. CCS Associates, Mountain View, CA, USA

    Caroline C. Sigman PhD

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Keith, R.L., Miller, Y.E., Bunn, P.A., Nana-Sinkam, P., Nemenoff, R.A., Geraci, M.W. (2004). Prostacyclin and Lung Cancer Chemoprevention. In: Kelloff, G.J., Hawk, E.T., Sigman, C.C. (eds) Cancer Chemoprevention. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-767-3_11

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  • DOI: https://doi.org/10.1007/978-1-59259-767-3_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-342-8

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