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Management of Urinary Tract Infections Caused by Multiresistant Organisms

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Management of Multiple Drug-Resistant Infections

Part of the book series: Infectious Disease ((ID))

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Abstract

During the 1970s and 1980s, there was much interest in the treatment of urinary tract infections (UTIs). The engine that drove the clinical trials was that many novel antibiotics (e.g., β-lactams and early fluoroquinolones) were being produced, resulting in many phase II and III clinical trials because UTIs, especially complicated infections, proved a good test bed for therapeutic efficacy of these compounds. There were also many protocols designed to develop shortened courses of treatment, typified by a prolonged (but ultimately unsuccessful) dalliance with “single-dose therapy” (1), and investigations into the possible usefulness of antibody-coated bacteria as a marker of upper tract involvement. In recent years, there have been fewer trials because the fewer new compounds becoming available have been mainly for lower respiratory tract infection (e.g., new macrolides and fluoroquinolones) or specifically aimed at multiresistant Gram-positive cocci (e.g., linezolid and quinupristin/dalfopristin), which do not commonly give rise to UTIs. Thus, recent research in this field has mainly consisted of meta-analyses and surveys of resistance and bacterial virulence factors.

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  1. Jeremy M. T. Hamilton-Miller
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Editors and Affiliations

  1. Department of Medical Microbiology, Royal Free and University College Medical School, London, England

    Stephen H. Gillespie MD, FRCP, FRCPath

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Hamilton-Miller, J.M.T. (2004). Management of Urinary Tract Infections Caused by Multiresistant Organisms. In: Gillespie, S.H. (eds) Management of Multiple Drug-Resistant Infections. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-738-3_10

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  • DOI: https://doi.org/10.1007/978-1-59259-738-3_10

  • Publisher Name: Humana Press, Totowa, NJ

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