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Computer Simulations of Cancellous Bone Remodeling

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The Skeleton

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Abstract

The bone remodeling process is essential for the maintenance of our skeleton. It enables adaptation of the bone mass and architecture to changes in external loads (1,2), and it prevents accumulation of damage (3,4). Damage accumulation is prevented by a frequent turnover of the bone tissue by the bone remodeling process: old tissue is replaced by new tissue. Bone remodeling is performed by two types of cells: osteoclasts, which are multinucleated bone resorbing cells, and osteoblasts, which are bone-forming cells. Osteoclasts resorb packets of bone tissue, and osteoblasts replace the resorbed tissue with new mineralized bone tissue (see Fig. 1).

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Authors
  1. Jacqueline C. van der Linden
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  2. Harrie Weinans
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  3. Jan A. N. Verhaar
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Editor information

Editors and Affiliations

  1. Developmental Biology Branch, Reproductive Toxicology Division, The National Health and Environmental Effects Research Laboratory, Office of Research Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA

    Edward J. Massaro  & John M. Rogers  & 

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© 2004 Springer Science+Business Media New York

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van der Linden, J.C., Weinans, H., Verhaar, J.A.N. (2004). Computer Simulations of Cancellous Bone Remodeling. In: Massaro, E.J., Rogers, J.M. (eds) The Skeleton. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-736-9_17

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  • DOI: https://doi.org/10.1007/978-1-59259-736-9_17

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-427-2

  • Online ISBN: 978-1-59259-736-9

  • eBook Packages: Springer Book Archive

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