Abstract
Stem cell definitions vary and often reflect how their properties are measured (1–4). Here, it is illustrated that stem cells can also be defined phylogenetically as common ancestors or “mothers” of cell groups. This approach is essentially fate mapping, but uses sequences instead of histologically visible markers to trace ancestry. An advantage of using sequences to trace somatic cell fates is the lack of a requirement for prior experimental intervention. Unlike definitions based on potential stem cell behaviors in experimental settings, a phylogenetic approach reconstructs how stem cells behave in unmanipulated intact organisms.
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Shibata, D. (2004). Stem Cells As Common Ancestors. In: Turksen, K. (eds) Adult Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-732-1_16
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DOI: https://doi.org/10.1007/978-1-59259-732-1_16
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61737-392-3
Online ISBN: 978-1-59259-732-1
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