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Engineering the In Vitro Cellular Microenvironment for the Control and Manipulation of Adult Stem Cell Responses

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Adult Stem Cells

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Abstract

Stem cells have generated a great deal of excitement as a potential source of cells for transplantation because of their ability to self-renew and differentiate into functional cells of various tissues (1–3). Stem cells can be derived from multiple stages of development as well as numerous adult tissues. Adult tissues are an attractive and readily accepted source of stem cells because such cells have demonstrated efficacy in multiple types of cellular therapeutics (4,5) and can be directly obtained from individual patients, thereby eliminating the difficulties associated with tissue rejection. Despite this enormous potential, the use of adult stem cells has been limited, primarily because of the inability to identify these rare cells from the heterogeneous tissue populations (6) and to expand populations of cells that retain stem cell properties in vitro.

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  1. Ali Khademhosseini
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  2. Peter W. Zandstra
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  1. Hormones, Growth, and Development Program, Ottawa Health Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada

    Kursad Turksen

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Khademhosseini, A., Zandstra, P.W. (2004). Engineering the In Vitro Cellular Microenvironment for the Control and Manipulation of Adult Stem Cell Responses. In: Turksen, K. (eds) Adult Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-732-1_15

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